Impaired serial ordering in nondemented patients with mild Parkinson's disease

PloS One
Jinghong MaZheng Ye

Abstract

The ability to arrange thoughts and actions in an appropriate serial order (the problem of serial order) is essential to complex behaviors such as language, reasoning and cognitive planning. Patients with Parkinson's disease (PD) perform poorly in tasks that rely on the successful rearrangement of working memory representations. We hypothesized that serial ordering is impaired in nondemented patients with mild PD. We recruited 49 patients with mild idiopathic PD (Hoehn and Yahr Scale 1-2.5) and 51 matched healthy adults. Nineteen patients had normal global cognition (PD-NC, Montreal Cognitive Assessment, MoCA≥26/30) and thirty patients had mild cognitive impairment (PD-MCI, 21≤MoCA≤25). All participants underwent three working memory assessments: two experimental tests that require reordering random digits following a particular rule (adaptive digit ordering test and digit span backward test) and a control test that requires maintaining but no reordering (digit span forward test). PD-NC and PD-MCI patients performed significantly worse (with lower test scores and larger ordering costs) than healthy controls in both digit ordering and backward tests, although they performed normally in the forward test. The ordering cost increas...Continue Reading

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Citations

Oct 25, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Zheng YeThomas F Münte
Feb 2, 2021·Neuropsychology Review·Ari Alex Ramos, Liana Machado
Apr 17, 2021·Neuropsychology Review·Elizabeth R WallaceLisa M Koehl

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