PMID: 1296Dec 1, 1975

Impaired Sertoli cell function in experimental cryptorchidism in the rat

Molecular and Cellular Endocrinology
L Hagenäs, E M Ritzen

Abstract

The production of testicular androgen-binding protein (ABP), as a measure of Sertoli cell function, was studied after unilateral or bilateral experimental cryptorchidism in adult rats. Two or 4 weeks after the testis had been translocated to the abdomen, no major changes were found in the concentration of ABP per mg protein, although there was a marked and progressive decrease in ABP content per testis. However, the rate of ABP production was greatly decreased, as measured by the accumulation of ABP during 16-h ligation of the efferent ducts or by the production of ABP by testis mince in an in vitro system. This indicates that the Sertoli cell function is severly impaired by the intra-abdominal position.

References

Jan 1, 1975·Current Topics in Molecular Endocrinology·V HanssonS N Nayfeh
Nov 14, 1973·Nature: New Biology·V HanssonF S French
Jul 25, 1959·Nature·B V SMITH, D LACY

Citations

Oct 1, 1977·Molecular and Cellular Endocrinology·E M RitzenV Hansson
Jul 1, 1988·Molecular and Cellular Endocrinology·G Pinon-LatailladeB Jegou
Jun 1, 1994·International Journal of Andrology·J van der GrondC J van Echteld
Feb 6, 2010·The Journal of Reproduction and Development·Bhuminand DevkotaYoh-Ichi Miyake
Mar 1, 1986·Environmental Health Perspectives·T J Gray, S D Gangolli
Jul 24, 2004·International Journal of Andrology·Zhi-Hong ZhangYi-Xun Liu
Jan 1, 1989·Zentralblatt für Veterinärmedizin. Reihe A·L Malmgren, K Larsson
Aug 1, 1986·International Journal of Andrology·V SyedE M Ritzen
Apr 1, 1984·International Journal of Andrology·B KarpeE M Ritzen
Apr 30, 1981·Nature·R M SharpeF F Rommerts
Jan 1, 1982·Annals of the New York Academy of Sciences·R M SharpeF F Rommerts
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R Hatier, G Grignon
Apr 1, 1981·International Journal of Andrology·B KarpeE M Ritzen
Feb 1, 1982·International Journal of Andrology·B KarpeE M Ritzen
Oct 1, 1984·International Journal of Andrology·A Bergh, J E Damber
Sep 26, 2012·Cellular and Molecular Life Sciences : CMLS·Byunghyuk KimKunsoo Rhee
May 1, 1986·Journal of Andrology·R M Pelletier, D S Friend
Mar 1, 1983·Journal of Andrology·L Seethalakshmi, A Steinberger
Mar 1, 1995·Andrologia·S C RubensteinA Morgentaler
Jan 1, 1983·Journal of Andrology·B JegouD M de Kretser

Related Concepts

Unilateral Cryptorchidism
Epididymis
Plasma Protein Binding Capacity
Hormone Receptors, Cell Surface
Scrotum
Structure of Sertoli Cell
Testis
Sterotate

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.