PMID: 9438804Jan 23, 1998Paper

Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats

Behavioral Neuroscience
Y C LiuB D Sachs

Abstract

N-methyl-D-aspartic acid (NMDA) or radiofrequency (RF) lesions were made in the paraventricular nucleus of the hypothalamus (PVH) of male rats. The rats were tested for copulation, noncontact erection (NCE) evoked by remote cues from estrous females, and (after RF lesions) reflexive erection. NMDA, which destroyed parvocellular but spared magnocellular neurons, caused no deficits in copulation but caused longer NCE latencies and fewer NCEs. Rats with RF lesions had parvo- and magnocellular neuron damage; these males copulated to ejaculation, but they had lower intromission ratios and longer ejaculatory latencies. RF-lesioned rats also had longer NCE latencies, and a smaller proportion of males displayed reflexive erection. Results indicate that the PVH participates in mediating erectile function in copula and ex copula, and that the parvo- and magnocellular PVH neurons may have different roles in mediating erection.

Citations

Jun 22, 1999·Hormones and Behavior·J ManzoB D Sachs
Feb 19, 2014·Pharmacology, Biochemistry, and Behavior·Ryan G WillJuan M Dominguez
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Jul 6, 2000·Neuroscience and Biobehavioral Reviews·F Giuliano, O Rampin
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Argiolas
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ana C RibeiroDonald W Pfaff
Feb 13, 2013·Behavioral Neuroscience·Jennifer A CummingsJill B Becker
Nov 17, 2005·BJU International·Ion G Motofei, David L Rowland

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