Impaired small-world network efficiency and dynamic functional distribution in patients with cirrhosis.

PloS One
Tun-Wei HsuChing-Po Lin

Abstract

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome and a major complication of liver cirrhosis. Dysmetabolism of the brain, related to elevated ammonia levels, interferes with intercortical connectivity and cognitive function. For evaluation of network efficiency, a 'small-world' network model can quantify the effectiveness of information transfer within brain networks. This study aimed to use small-world topology to investigate abnormalities of neuronal connectivity among widely distributed brain regions in patients with liver cirrhosis using resting-state functional magnetic resonance imaging (rs-fMRI). Seventeen cirrhotic patients without HE, 9 with minimal HE, 9 with overt HE, and 35 healthy controls were compared. The interregional correlation matrix was obtained by averaging the rs-fMRI time series over all voxels in each of the 90 regions using the automated anatomical labeling model. Cost and correlation threshold values were then applied to construct the functional brain network. The absolute and relative network efficiencies were calculated; quantifying distinct aspects of the local and global topological network organization. Correlations between network topology parameters, ammonia levels, and the se...Continue Reading

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Citations

Oct 25, 2013·Radiology·Qijun ShenLiang Zhang
Jul 22, 2014·European Journal of Radiology·Long Jiang ZhangGuang Ming Lu
Apr 22, 2014·Seminars in Ultrasound, CT, and MR·Juli AlonsoAlex Rovira
Sep 18, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wei-Che LinChing-Po Lin
Sep 28, 2015·Psychiatry Research·Tsung-Wei SuChing-Po Lin
Jul 2, 2014·Frontiers in Neurology·Martijn BeudelMichel J A M van Putten
Apr 16, 2015·PloS One·Matthew L StanleyPaul J Laurienti
Aug 31, 2013·PloS One·Felix SiebenhühnerDanielle S Bassett
Jan 28, 2018·Metabolic Brain Disease·Xiao Dong Zhang, Long Jiang Zhang
Aug 30, 2014·World Journal of Gastroenterology : WJG·Xiao-Dong ZhangGuang-Ming Lu
May 2, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Gaoyan ZhangShuangshuang Xie
Oct 8, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ying LiZuojun Geng

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS
SPM8
fMRI
SPM
Data Processing Assistant for Resting - State fMRI ( DPARSF )

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