PMID: 3762122Aug 1, 1986Paper

Impaired specific cell-mediated immunity in experimental biliary obstruction and its reversibility by internal biliary drainage

The Journal of Surgical Research
P T RoughneenB J Rowlands

Abstract

Little is known of the effect of cholestasis on host immunity. This study evaluates lymphocytic responsiveness to PHA and LPS mitogen and to allogeneic F344 antigen in Sprague-Dawley rats 21 days following bile duct ligation and 31 days following relief of jaundice by internal biliary drainage. Serum bilirubin level was significantly elevated in the bile duct ligated animals at Day 21 (P less than 0.001) and thereafter returned to preoperative levels following internal biliary drainage. Results demonstrate depressed responsiveness to PHA (P less than 0.001) and allogeneic F344 antigen in vivo (P less than 0.04) and in vitro (P less than 0.02) in bile duct ligated animals as compared to sham, sham pair-fed, and normal control rats. The observed deficiency in responsiveness to T-cell-dependent mitogen and antigen cannot be explained on the basis of complicating nutritional, renal, or infective factors. Subsequent internal biliary drainage results in some improvement in T-cell responsiveness in the bile duct ligated group although recovery is not complete. B-Lymphocytic response to LPS mitogen is not affected by bile duct ligation. We conclude that cholestasis subsequent to extrahepatic biliary obstruction per se results in impair...Continue Reading

References

May 1, 1975·The Journal of Pediatrics·M Rola-PlezczynskiJ A Bellanti
Dec 1, 1979·American Journal of Surgery·J M HolmanF G Moody
Oct 1, 1976·The British Journal of Surgery·M E Bailey
Nov 1, 1977·The Journal of Surgical Research·C J RyanL H Blumgart
Jun 26, 1976·British Medical Journal·G DrivasN Wardle
Nov 21, 1970·British Medical Journal·E N Wardle, N A Wright
Jan 1, 1980·Acta Haematologica·E N Wardle, R Williams
Jan 1, 1984·Annals of Surgery·S KatzT R Weber
May 1, 1984·The British Journal of Surgery·G A McPhersonL H Blumgart
Mar 1, 1984·The British Journal of Surgery·C P ArmstrongG C Davies
Sep 1, 1983·The British Journal of Surgery·S L BlameyD C Carter
May 1, 1982·The British Journal of Surgery·G A McPhersonL H Blumgart
Jan 1, 1981·American Journal of Surgery·H A PittT R Gadacz
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·G MaggioreA Vitiello
Aug 1, 1980·Clinical Immunology and Immunopathology·M Pinto, A Kaplun

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Citations

Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H LiJ P Xiang
Jan 1, 1993·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H LiY Luo
Jan 1, 1991·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H LiZ H Feng
Jan 25, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chang-Sup LimSun-Whe Kim
Oct 23, 2013·The International Journal of Biochemistry & Cell Biology·Sushrut JangiSimon Robson
Jul 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H GerkeJ Baillie
Jun 13, 2001·Journal of the American College of Surgeons·M E SewnathD J Gouma
Nov 1, 1987·Annals of Surgery·P T RoughneenB J Rowlands
Nov 29, 2012·The Cancer Journal·Johanna A M G TolDirk J Gouma
Jul 1, 1994·Journal of Gastroenterology and Hepatology·S T FanJ Wong
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Jan 22, 2011·World Journal of Gastroenterology : WJG·Yu-Dong QiuYi-Tao Ding
Aug 30, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·N A van der GaagD J Gouma
Jul 1, 1988·The American Journal of the Medical Sciences·T D FeducciaJ B Grogan
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Timothy J KennedyWilliam R Jarnagin
Mar 18, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dirk J Gouma
Nov 26, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew C LoftspringJoseph F Clark
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rodrigo JoverMiguel Pérez-Mateo
Apr 1, 1991·Journal of Pediatric Surgery·S KatzJ L Grosfeld
Jul 1, 1987·American Journal of Surgery·C A PellegriniL W Way
Feb 1, 1990·Journal of Pediatric Surgery·P T RoughneenB J Rowlands
Apr 1, 1987·The Journal of Surgical Research·H F StarnesM F Brennan
Sep 13, 2005·The Journal of Surgical Research·J S WhiteT Diamond
Jun 19, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kaya YorganciIskender Sayek
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·J W GreveW A Buurman
Nov 1, 1990·The British Journal of Surgery·R L ThompsonB J Rowlands
May 1, 1991·The British Journal of Surgery·D J GoumaM H Bemelmans
Jul 1, 1993·The British Journal of Surgery·W D ClementsB J Rowlands
Jul 1, 1992·The British Journal of Surgery·J W DingS Bengmark
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C H DejongP B Soeters
Aug 1, 1994·The British Journal of Surgery·J A KennedyB J Rowlands
Feb 1, 1994·The British Journal of Surgery·M C ReganD Bouchier-Hayes

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