PMID: 11926407Apr 3, 2002Paper

Impaired surface antigen presentation in tumors: implications for T cell-based immunotherapy

Seminars in Cancer Biology
F Ruiz-CabelloF Garrido

Abstract

The identification of tumor-associated antigens has suggested new possibilities for cancer therapy. However, multiple mechanisms may contribute to the ability of tumor to escape antitumor immune responses. Tumor antigen heterogeneity, modulation of HLA expression and immune suppressive mechanisms may occur at any time during tumor cell progression, and can affect the outcome of therapeutic immune intervention. In particular, the appearance of altered HLA class I phenotypes during tumor development may have important biological and medical implications due to the role of these molecules in T and NK cell functions. Exhaustive tumor tissue studies are necessary before deciding whether a particular patient is suitable for inclusion in T cell-based immunotherapy protocols.

Citations

Nov 18, 2014·Journal of Immunology Research·Thomas KraemerChristina Bade-Doeding
Sep 10, 2005·Nature Biotechnology·Anna M Wu, Peter D Senter
Sep 28, 2004·Cancer Immunology, Immunotherapy : CII·Matthias WölflFrank Berthold
Jul 11, 2007·International Journal of Cancer. Journal International Du Cancer·Laura PacoMiguel Angel Lopez-Nevot
Jul 12, 2007·Cancer Immunology, Immunotherapy : CII·Akash M MehtaGert-Jan Fleuren
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Jose Manuel CózarFrancisco Ruiz-Cabello Osuna
Jun 10, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qian JiangZhi-yuan Zhang
Nov 21, 2019·Vaccines·Petr G LokhovElena E Balashova
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Qian-Jin ZhangWilfred A Jefferies
Mar 6, 2003·Immunogenetics·Rosario MarínFederico Garrido
Aug 10, 2021·The Journal of Biological Chemistry·Nadia AnikeevaYuri Sykulev

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