Impaired sympathetic influence on the immune response in patients with rheumatoid arthritis due to lymphocyte subset-specific modulation of beta 2-adrenergic receptors

British Journal of Rheumatology
C G BaerwaldA Krause

Abstract

Previous studies have demonstrated that an alteration of the interaction between the immune system and the autonomic nervous system may contribute to the pathogenesis of inflammatory arthritides. To address this issue further in patients with rheumatoid arthritis (RA), this study aimed at determining the modulation of beta-adrenergic receptors (beta 2R) on lymphocyte subsets and its impact on cell reactivity. beta 2R were determined on CD4+ and CD8+ peripheral blood lymphocytes (PBL) and synovial fluid lymphocytes (SFL) from RA patients and normal donors. In parallel, the influence of catecholamines on OKT3-induced T-cell activation was studied. In patients with RA, beta 2R on SFL were significantly decreased compared to beta 2R on PBL. Furthermore, a disease activity-correlated significant decrease of beta 2R on CD8+ PBL was observed. This decrease of beta 2R was paralleled by a reduced suppressive effect of catecholamines on OKT3-induced lymphocyte proliferation. Our data give further evidence for an impaired sympathetic influence on the immune response in RA.

Citations

Dec 14, 2011·Amino Acids·Franca Marino, Marco Cosentino
Jul 19, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M WahleC G O Baerwald
Jan 3, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Danielle C OrreySamuel A McLean
Mar 21, 2007·International Journal of Clinical Practice·D A AnichkovD S Ivanov
Jul 23, 1999·Annals of the New York Academy of Sciences·M WahleC G Baerwald
Jul 23, 1999·Annals of the New York Academy of Sciences·M WahleC G Baerwald
Jul 13, 2002·Annals of the New York Academy of Sciences·M WahleC G O Baerwald
Jul 27, 1999·Annals of the Rheumatic Diseases·E ToussirotJ Regnard
Apr 17, 2001·Annals of the Rheumatic Diseases·M WahleC G Baerwald
Nov 7, 2013·Clinical & Developmental Immunology·Dianne LortonCheri Lubahn
Dec 19, 2003·Arthritis Research & Therapy·Farideh EskandariEsther M Sternberg
May 19, 2010·Arthritis Research & Therapy·Sabine J M de BrouwerAndrea W M Evers
Jan 21, 2016·Arthritis Research & Therapy·Janet BeckmannKatrin Susanne Lips
Oct 9, 2007·Journal of Neuroimmunology·Jian-Lan JiangJian-Jun Wang
Apr 2, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yongping BaiYaoxing Chen
Mar 20, 2014·The British Journal of Dermatology·S J M de BrouwerA W M Evers
Mar 1, 2008·Cellular Immunology·Denise L BellingerDianne Lorton
Sep 29, 2006·Autonomic Neuroscience : Basic & Clinical·Yulan DongJi-Long Chen
Jan 11, 2005·Rheumatic Diseases Clinics of North America·Rainer H Straub, Peter Härle
Sep 15, 2004·Trends in Immunology·Sammy BedouiTakashi Yamamura
Nov 24, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jinling ShuWei Wei
Mar 25, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Didem SayginKewal Asosingh
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Maurizio CutoloJohannes W J Bijlsma
Mar 3, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark J BucsekElizabeth A Repasky
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·K PeuhkuriR Korpela
Jul 5, 2002·Brain, Behavior, and Immunity·Virginia M Sanders, Rainer H Straub

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