PMID: 7049972Jan 1, 1982Paper

Impaired T-cell functions in aged guinea-pigs restored by thymostimulin (TS)

International Journal of Immunopharmacology
R FalchettiL Caprino

Abstract

The age-related changes of different T-cell activities in guinea pigs and the effect of Thymostimulin (TS), a thymus extract, on the immunocompetence of these cells was studied. Mitogen-induced proliferation of peripheral blood lymphocytes was increased by TS in vitro. The intraperitoneal administration of TS (5 mg/kg) to aged animals restored the helper function of T lymphocytes and enhanced the reactivity to mitogens of both peripheral blood lymphocytes and spleen lymphocytes. The data obtained suggest that as in other species, there is an age-associated decline of immunological response, in guinea pigs too, probably due to a deficiency of thymic hormone(s) and that TS could correct this deficiency.

References

Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·V M LewisR A Good
Feb 14, 1978·Biochemical and Biophysical Research Communications·E G BliznakovK Folkers
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A L GoldsteinA White
Oct 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·Y HoriM K Halsall
Jan 1, 1974·Transplantation Reviews·N K JerneI Lefkovits
Jan 1, 1961·Gerontologia·P L KROHN

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