Impaired T lymphocyte immune response in vitamin A depleted rats and chicks.

The British Journal of Nutrition
A Friedman, D Sklan

Abstract

Vitamin A deficiency results in decreased immune responses; the objective of the present study was to investigate the involvement of T lymphocytes in the depression of immune responses resulting from vitamin A depletion. This objective was achieved by evaluating antigen-specific T lymphocyte proliferative responses in vitro as vitamin A depletion developed. The evaluation was performed in both rat and chick to examine the generality of immune effects due to vitamin A depletion. Our findings show that vitamin A depletion led to severe impairment of T lymphocyte activity in both animal models, and that this was directly related to the vitamin A status in both species. Immune response impairment was found to precede other manifestations of vitamin A deficiency, and was rapidly corrected by feeding retinyl acetate boluses. This implied a possible regulatory, rather than constitutive, role of vitamin A in immune responsiveness.

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Citations

Oct 1, 2009·Animal : an International Journal of Animal Bioscience·Z Y NiuY P Gao
Jan 27, 2018·Journal of Animal Science and Biotechnology·Ahmed Mohamed FouadChuntian Zheng
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
Feb 16, 2019·Frontiers in Veterinary Science·Sunday A Adedokun, Opeyemi C Olojede
Apr 1, 1997·The Journal of Nutrition·S S TwiningJ E Moulder
Feb 20, 2021·Poultry Science·Bahram ShojadoostShayan Sharif

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