Impaired Th2 subset development in the absence of CD4

Immunity
D J FowellR M Locksley

Abstract

Prior studies in CD4-deficient mice established the capacity of T helper (Th) lineage cells to mature into Th1 cells. Unexpectedly, challenge of these mice with Nippostrongylus brasiliensis, a Th2-inducing stimulus, failed to result in the development of Th2 cells. Additional studies were performed using CD4+ or CD4-CD8- (double-negative) T cell receptor (TCR) transgenic T cells reactive to LACK antigen of Leishmania major. Double-negative T cells were unable to develop into Th2 cells in vivo, and, unlike CD4+ T cells, could not be primed for interleukin-4 production in vitro. Similarly, CD4+ TCR transgenic T cells primed on antigen-presenting cells expressing mutant MHC class II molecules unable to bind CD4 did not differentiate into Th2 cells. These data suggest that interactions between the TCR, MHC II-peptide complex and CD4 may be involved in Th2 development.

References

Jun 11, 1992·Immunological Reviews·J F UrbanF D Finkelman
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Dec 1, 1989·The Journal of Experimental Medicine·J S MurrayK Bottomly
Nov 1, 1995·The Journal of Experimental Medicine·S ConstantK Bottomly
Apr 1, 1995·The Journal of Experimental Medicine·C PfeifferK Bottomly
Apr 28, 1995·Science·E MougneauN Glaichenhaus
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R A Seder
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Sep 1, 1994·European Journal of Immunology·A RahemtullaT W Mak
Jun 30, 1994·Nature·S C JamesonM J Bevan
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D QianF W Fitch
Aug 19, 1993·Nature·N Killeen, D R Littman
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·U MoebiusE L Reinherz
Mar 5, 1993·Science·S L ReinerR M Locksley
May 1, 1996·The Journal of Experimental Medicine·D A VignaliJ L Strominger
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C A Mallick-WoodA C Hayday
Oct 1, 1996·The Journal of Experimental Medicine·D R BrownS L Reiner
Oct 31, 1996·Nature·A K AbbasA Sher
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D GorhamK M Murphy

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Citations

Nov 26, 1999·Cancer·H D Preisler
Mar 27, 2001·European Journal of Immunology·M P RileyA J Caton
Sep 24, 1999·Immunologic Research·D P Metz, K Bottomly
Sep 1, 1999·Immunologic Research·W C GauseJ F Urban
May 13, 1998·Immunology Today·J S Murray
Mar 11, 1998·Current Opinion in Immunology·A Hayday, L Geng
Sep 2, 1998·Current Opinion in Immunology·J LouisP Launois
May 29, 1998·Current Opinion in Immunology·K M Murphy
Jun 5, 2003·International Immunopharmacology·Kiyoshi Takatsu, Ai Kariyone
Apr 2, 2005·Nature Reviews. Immunology·Pamela L SchwartzbergJulie A Readinger
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·J StrongN Killeen
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M RiberdyC Doyle
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·P M SelzerJ H McKerrow
Nov 6, 1998·The Journal of Experimental Medicine·A E WakilR M Locksley
Apr 6, 1999·The Journal of Experimental Medicine·S PingelR M Locksley
Dec 19, 2001·The Journal of Experimental Medicine·Q WangN Killeen
Feb 11, 2004·The Journal of Experimental Medicine·Aaron J TyznikMichael J Bevan
Dec 16, 1998·Immunological Reviews·S ChanD Mathis
Jun 3, 2000·Annual Review of Immunology·K M MurphyT L Murphy
Mar 7, 2002·International Reviews of Immunology·T D BrumeanuS Casares
Mar 1, 2006·Expert Review of Clinical Immunology·David J TophamMartin Richter
Feb 25, 2009·Cytokine·Deborah J Fowell
Sep 4, 2015·Diabetology & Metabolic Syndrome·Bradley T GaoVanessa M Morales-Tirado
Apr 27, 2013·International Reviews of Immunology·Leonardo M R Ferreira
Jul 5, 2005·Expert Opinion on Investigational Drugs·M MarinaroJ R McGhee
Aug 11, 1999·Seminars in Immunology·D Leitenberg, K Bottomly
Sep 5, 1998·Immunity·J J BirdS L Reiner
Apr 23, 2003·Immunity·Joaquín Madrenas
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A K DeC L Miller-Graziano

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