Impaired thermal perception in cluster headache.

Journal of Neurology
Jens EllrichS Said Yekta

Abstract

Cluster headache is characterized by attacks of severe periorbital pain. Repetitive burst activity in afferent fibers may induce plastic alterations in somatosensory synaptic processing as a prerequisite for recurring and chronic pain. This psychophysical study addressed hypothesized dysfunctions in craniofacial somatosensory processing in cluster headache disease. Thermal and mechanical sensory functions in the periorbital region were assessed by quantitative sensory testing (QST) in 25 cluster headache patients and 60 healthy volunteers. Perception of warmth (p<0.01), cold (p<0.000001), and pressure pain (p<0.05) was reduced on the cluster side as compared with the contralateral asymptomatic side. In contrast to healthy volunteers, warm detection threshold (WDT) and thermal sensory limen (TSL) on one side did not positively correlate with the other side. WDT and TSL negatively correlated with the elapsed time since last attack. All patients showed QST abnormalities on the headache side in comparison to healthy controls. Loss of sensory functions strongly preponderated gain. Several lines of evidence indicate a pivotal role of the hypothalamus in cluster headache pathophysiology. The impairment of warm and cold perception in p...Continue Reading

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Citations

Mar 21, 2007·Current Pain and Headache Reports·Alexandre F M DaSilvaDavid Borsook
Apr 13, 2007·Cephalalgia : an International Journal of Headache·J EllrichS Said Yekta
Jun 13, 2008·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
Jun 13, 2008·Cephalalgia : an International Journal of Headache·A May
Oct 28, 2010·Head & Face Medicine·Sareh Said YektaRalf Smeets
Aug 2, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sareh Said-YektaFriedrich Lampert
Jul 6, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sareh Said YektaJens Ellrich
Apr 19, 2015·Head & Face Medicine·Sareh Said Yekta-MichaelErnst Marioth-Wirtz
Aug 1, 2013·The Journal of Headache and Pain·Gianluca CoppolaFrancesco Pierelli
Jan 15, 2016·Cephalalgia : an International Journal of Headache·Henrik Winther Schytz, Jes Olesen
Mar 2, 2018·Nature Reviews. Disease Primers·Arne MayShuu-Jiun Wang
Mar 9, 2011·Neurologia i neurochirurgia polska·Tomasz TykockiTomasz Mandat
Apr 15, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Miguel Malo-UrriésCésar Hidalgo-García
Mar 11, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Fernando G ExpostoPeter Svensson

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