Impaired Thymic Output Can Be Related to the Low Immune Reconstitution and T Cell Repertoire Disturbances in Relapsing Visceral Leishmaniasis Associated HIV/AIDS Patients.

Frontiers in Immunology
Maria Luciana Silva-FreitasJoanna Reis Santos-Oliveira

Abstract

Background: Visceral leishmaniasis/HIV-co-infected patients (VL/HIV) accounts for around 8% of VL reported cases in Brazil. Relapses of Leishmania infection after anti-leishmanial treatment constitute a great challenge in the clinical practice because of the disease severity and drug resistance. We have shown that non-relapsing-VL/HIV (NR-) evolved with increase of CD4+ T-cell counts and reduction of activated CD4+ and CD8+ T cells after anti-leishmanial treatment. This immune profile was not observed in relapsing-VL/HIV patients (R-), indicating a more severe immunological compromising degree. Elevated activation status may be related to a deficient immune reconstitution and could help to explain the frequent relapses in VL/HIV co-infection. Our aim was to evaluate if this gain of T cells was related to changes in the peripheral TCRVβ repertoire and inflammatory status, as well as the possible thymus involvement in the replenishment of these newly formed T lymphocytes. Methods: VL/HIV patients, grouped into non-relapsing (NR- = 6) and relapsing (R- = 12) were evaluated from the active phase up to 12 months post-treatment (mpt). HIV-infected patients (non-VL) and healthy subjects (HS) were included. The TCRVβ repertoire was eva...Continue Reading

References

Apr 14, 2000·The Journal of Infectious Diseases·D C DouekK Luzuriaga
Apr 14, 2004·Current HIV Research·Ping YeAthena P Kourtis
Jul 19, 2006·PLoS Pathogens·Wilson Savino
Feb 20, 2007·Experimental Gerontology·Victor AppayLaura Papagno
May 26, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dimitri SalameireMarie-Christine Jacob
Jan 1, 2013·Current Opinion in HIV and AIDS·Edwin LeeansyahJohan K Sandberg
May 21, 2013·Pathogens and Global Health·Dorcas L CostaAldina P Barral
Apr 20, 2014·PLoS Neglected Tropical Diseases·Gláucia F CotaAna Rabello
Oct 7, 2015·Nature Reviews. Endocrinology·Wilson SavinoMireille Dardenne
Dec 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Rosado-SánchezYolanda M Pacheco
Feb 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara Ferrando-MartinezEzequiel Ruiz-Mateos
Mar 30, 2017·PLoS Neglected Tropical Diseases·Ricardo Luís Louzada SilvaAmélia Ribeiro Jesus
May 12, 2017·Journal of Chemotherapy·Pasquale Pagliano, Silvano Esposito
Oct 24, 2017·Clinical and Experimental Immunology·P KumarD K Mitra
Dec 7, 2017·Mediators of Inflammation·T SokoyaT M Rossouw
Nov 10, 2018·HIV/AIDS : Research and Palliative Care·José Angelo Lauletta LindosoIgor Thiago Queiroz
Mar 27, 2019·PloS One·Aline Mireille da Cunha FievezAlda M Da-Cruz
Jul 30, 2019·Frontiers in Cellular and Infection Microbiology·Monica Losada-BarragánPatricia Cuervo
Sep 3, 2019·AIDS Research and Human Retroviruses·Robert L FurlerDouglas F Nixon

❮ Previous
Next ❯

Citations

Dec 3, 2020·Frontiers in Immunology·Marina Andrade BatistaAna Maria Caetano Faria
Apr 21, 2021·BMC Infectious Diseases·Renata Caetano KuschnirAlda Maria Da-Cruz

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
Fluorescence

Software Mentioned

GraphPad Prism
500
Cell Quest Pro TM
Heat mapper®

Related Concepts

Related Feeds

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.