Impaired topographic organization in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson's disease

Parkinsonism & Related Disorders
Yanbing HouHuifang Shang

Abstract

Resting-state functional magnetic resonance imaging (fMRI) and graph theory approaches have been combined to investigate the topographic organization in Parkinson's disease (PD). Twenty cognitively unimpaired drug-naïve patients with rigidity-dominant PD (PDAR) and 20 age-, sex-, and education-matched healthy controls were included. Small-world profile and topographic properties (clustering coefficient (Cp), characteristic path length (Lp), local efficiency (Eloc), global efficiency (Eglob), nodal efficiency (Enod), nodal degree (NDeg), and nodal betweenness (NBet)) were measured and compared between two groups, with age, gender and education as covariates. Correlation analyses between topographic features and the unified PD rating scale part-III (UPDRS-III) scores, cognitive scores were performed. PDAR patients presented the small-world property, and abnormalities at the nodal level (Enod, NDeg, and NBet) but not at the global level (Cp, Lp, Eloc, and Eglob). Our results revealed lower nodal centralities mainly in the occipital lobe and areas of the limbic system (including amygdala nucleus), and higher nodal centralities in distributed frontal and temporal regions. Notably, the decreased nodal efficiency of occipital regions ...Continue Reading

Citations

Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Patrícia KlobušiakováIrena Rektorová
Aug 28, 2019·Journal of Parkinson's Disease·Alessandro TessitoreRosa De Micco
Jun 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Wichmann
Feb 28, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Rosa De MiccoAlessandro Tessitore
May 11, 2020·Journal of the Neurological Sciences·Yanbing HouHuifang Shang

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