Impaired topological architecture of brain structural networks in idiopathic Parkinson's disease: a DTI study

Brain Imaging and Behavior
Changhong LiRuiwang Huang

Abstract

Parkinson's disease (PD) is considered as a neurodegenerative disorder of the brain central nervous system. But, to date, few studies adopted the network model to reveal topological changes in brain structural networks in PD patients. Additionally, although the concept of rich club organization has been widely used to study brain networks in various brain disorders, there is no study to report the changed rich club organization of brain networks in PD patients. Thus, we collected diffusion tensor imaging (DTI) data from 35 PD patients and 26 healthy controls and adopted deterministic tractography to construct brain structural networks. During the network analysis, we calculated their topological properties, and built the rich club organization of brain structural networks for both subject groups. By comparing the between-group differences in topological properties and rich club organizations, we found that the connectivity strength of the feeder and local connections are lower in PD patients compared to those of the healthy controls. Furthermore, using a network-based statistic (NBS) approach, we identified uniformly significantly decreased connections in two modules, the limbic/paralimbic/subcortical module and the cognitive c...Continue Reading

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Citations

Jul 5, 2016·Frontiers in Human Neuroscience·Umberto di Porzio
Aug 11, 2016·Frontiers in Human Neuroscience·Alberto CacciolaAngelo Quartarone
Jun 10, 2017·Brain Connectivity·Apurva ShahMadhura Ingalhalikar
Nov 11, 2018·Human Brain Mapping·Gong-Jun JiKai Wang
Apr 20, 2019·Journal of Neurosciences in Rural Practice·Thomas J BuellKenneth C Liu
Mar 4, 2020·The International Journal of Neuroscience·Rutvi Prajapati, Isaac Arnold Emerson
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Feb 9, 2017·Journal of Neurology·Farzaneh Rahmani, Mohammad Hadi Aarabi
Jun 19, 2018·Brain Imaging and Behavior·Alessandro ArrigoAngelo Quartarone
Jun 27, 2021·Brain Structure & Function·Tiantian LiuTianyi Yan
Aug 20, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Chris VriendOdile A van den Heuvel

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Methods Mentioned

BETA
imaging technique

Software Mentioned

BCT
SFGdor
CAL
PreCG
DTIStudio
GRETNA
FDT Toolbox
FSL
SFGmed

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