Impaired transcallosally mediated motor inhibition in adults with attention-deficit/hyperactivity disorder is modulated by methylphenidate

Journal of Neural Transmission
Jacqueline HoeppnerJohannes Buchmann

Abstract

Using transcranial magnetic stimulation (TMS) in children with ADHD, an impaired transcallosally mediated motor inhibition (ipsilateral silent period, iSP) was found, and its restoration was correlated with improvement of hyperactivity under medication with methylphenidate (MPH). Hyperactivity has been reported to decrease during transition into adulthood, although some motor dysfunction might persist. As one underlying neurophysiological process, a development-dependent normalization of motor cortical excitability might be postulated. In order to test this hypothesis, we measured the iSP in 21 adult ADHD patients and twenty-one sex- and age-matched healthy controls. In 16 of these patients, a second TMS was performed under treatment with MPH. Our results indicate a persistence of impaired transcallosally mediated motor cortical inhibition (shortened duration) in ADHD adults, which was correlated with clinical characteristics of hyperactivity and restlessness, and was restored by MPH. In contrast to ADHD in childhood, the iSP latency was not impaired, suggesting a partial development-dependent normalization of motor cortical excitability in ADHD adults. ISP duration appears to be a sensitive parameter for the assessment of dist...Continue Reading

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Citations

Nov 7, 2008·Journal of Neural Transmission·Jacqueline HoeppnerJohannes Buchmann
Nov 15, 2011·Journal of Neural Transmission·Jacqueline HoeppnerStefan Teipel
Dec 24, 2010·Italian Journal of Pediatrics·Paolo CuratoloRomina Moavero
Sep 9, 2008·Child and Adolescent Psychiatric Clinics of North America·Susan E Levy, Susan L Hyman
Oct 10, 2008·Biological Psychiatry·Eileen LudersJennifer G Levitt
Dec 15, 2015·Journal of Child Neurology·Belen RubioAlvaro Pascual-Leone
Oct 23, 2014·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Thomas HoeglHartmut Heinrich

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