Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus

American Journal of Reproductive Immunology : AJRI
T F LoboS Daher

Abstract

Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood. In addition, the expression of IL-10, TGF-B, and TNF-A in Treg and expression of IFN-G, TNF-A, granzyme, and perforin in NK cells were analyzed. GDM patients had significantly lower frequency of TCD4+ CD25bright and TCD4+ CD25+ FOXP3high cells, higher production of TNF-A by Treg cells and higher percentage of NKCD16+ 56dim cells than the controls. The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.

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Citations

Feb 18, 2018·American Journal of Reproductive Immunology : AJRI·Tomoyuki Kawada
Dec 19, 2019·Scandinavian Journal of Immunology·Thiago P B De LucciaSilvia Daher
May 31, 2020·International Journal of Molecular Sciences·Lauren E St-GermainAlexander G Beristain
Nov 23, 2018·International Journal of Molecular Sciences·Nada A SallamJennifer A Thompson
Oct 23, 2019·International Journal of Molecular Sciences·Sébastien Le GarfAnne-Sophie Rousseau
Dec 12, 2018·Journal of Diabetes Research·Tong ZhouGuixia Wang
Jan 22, 2019·Reviews in Medical Microbiology : a Journal of the Pathological Society of Great Britain and Ireland·Antonio TonioloEle Ferrannini
Apr 4, 2021·International Journal of Molecular Sciences·Erasmia SampaniMaria Stangou
Jul 20, 2020·Reproductive Toxicology·Jerrold J HeindelR Thomas Zoeller
Apr 28, 2021·Molecular Reproduction and Development·Sheryl K MunroAnna P Ponnampalam
May 1, 2021·International Journal of Molecular Sciences·Colm J McElwainCathal M McCarthy
Aug 8, 2021·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina

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