Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats

Diabetologia
A SuárezA Rovira

Abstract

The effect of magnesium deficiency on glucose disposal, glucose-stimulated insulin secretion and insulin action on skeletal muscle was investigated in rats which were fed a low magnesium-containing diet for 4 days. Control rats were fed a standard diet. Compared to the control rats, the rats fed with low magnesium diet presented: 1) lower serum magnesium levels (0.45 +/- 0.02 vs 0.78 +/- 0.01 mmol/l, p < 0.001), 2) higher basal serum glucose (6.8 +/- 0.02 vs 5.5 +/- 0.2 mmol/l, p < 0.05) and similar basal serum insulin, 3) 40% reduction (p < 0.001) in the glucose disappearance rate after its i.v. administration, and 4) 45% reduction (p < 0.05) in the glucose-stimulated insulin secretion. The insulin action upon the glucose uptake by skeletal muscle was determined by means of hindquarter perfusions. Compared with control rats, magnesium-deficient rats presented: 1) normal basal glucose uptake, 2) lower stimulatory effect on the glucose uptake by insulin at the concentrations of 5 x 10(-10) mol/l (3.0 +/- 0.9 vs 5.4 +/- 0.6, p < 0.05) and 5 x 10(-9) mol/l (6.3 +/- 0.5 vs 8.0 +/- 0.5, p < 0.05), 3) normal glucose uptake at a maximal insulin concentration of 1 x 10(-7) mol/l, and 4) 50% reduction in the insulin sensitivity (ED50: 1...Continue Reading

References

Dec 1, 1975·The Biochemical Journal·G A George, F W Heaton
May 1, 1992·The American Journal of Clinical Nutrition·G A ColditzF E Speizer
Aug 1, 1985·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B VarnumN Venkatesan
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H FukumotoG I Bell
Feb 1, 1987·Metabolism: Clinical and Experimental·C LegrandJ C Henquin
Jan 2, 1973·Biochimica Et Biophysica Acta·A J Lostroh, M E Krahl
Jan 1, 1974·Advances in Enzyme Regulation·A J Lostroh, M E Krahl
Dec 1, 1973·Endocrinology·V Leclercq-MeyerW J Malaisse
Aug 14, 1970·Biochimica Et Biophysica Acta·M K Gould, I H Chaudry
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Dec 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E Gueux, Y Rayssiguier
Apr 7, 1984·British Medical Journal·C S YajnikN I Ward
Sep 15, 1983·Biochemical and Biophysical Research Communications·G GrunbergerP Gorden
Jul 24, 1982·British Medical Journal·K W Moles, J K McMullen
Apr 15, 1980·The Biochemical Journal·G L DohmG R Beecher
Mar 1, 1963·The Journal of Clinical Investigation·R WHANG, L G WELT
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER
Jul 1, 1950·Physiological Reviews·A L LEHNINGER

❮ Previous
Next ❯

Citations

May 23, 2012·Pharmaceutical Research·Ravikiran Panakanti, Ajit S Narang
Feb 18, 2009·Biological Trace Element Research·Sat Byul ParkAh Young Nam
Jul 2, 2011·Indian Pediatrics·Bipin JoseSavita Saini
Jan 23, 2003·Molecular Aspects of Medicine·Mario BarbagalloGiuseppe Paolisso
Aug 4, 2010·Journal of the American College of Nutrition·Kyoko KiriiUNKNOWN JACC Study Group
Dec 22, 2009·American Journal of Epidemiology·Yamini KesavanDominique S Michaud
Jan 17, 2008·Current Opinion in Lipidology·Simona Bo, Elisabetta Pisu
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G T SandersR Sanders
Feb 20, 2009·The American Journal of Clinical Nutrition·Raquel VillegasXiao Ou Shu
Dec 24, 2015·Diabetes·Lisanne M M GommersJeroen H F de Baaij
Feb 4, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Cristiane Hermes SalesCélia Colli
May 21, 2008·European Journal of Clinical Investigation·F Guerrero-RomeroN Wacher
Jun 23, 2011·Diabetes/metabolism Research and Reviews·Theodoros Thomas, Andreas F H Pfeiffer
Jun 10, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Steven Van LaeckeRaymond Vanholder
Jul 1, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·D T DibabaK He
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nurullah CelikAyse Esra Yilmaz
Nov 25, 2004·Metabolism: Clinical and Experimental·Junji TakayaYohnosuke Kobayashi
May 15, 2015·Diabetes, Obesity & Metabolism·Frank C Mooren
Feb 19, 2015·Acta Neuropsychiatrica·Gudrun WintherGregers Wegener
May 24, 2015·Transplantation Reviews·Steven Van Laecke, Wim Van Biesen
Jul 6, 2014·Nutrition·Muhammad Sajid Hamid AkashShuqing Chen
Apr 28, 2005·Diabetes Care·Milagros G HuertaJerry L Nadler
Dec 25, 2003·Diabetes Care·Ruy Lopez-RidauraFrank B Hu
Dec 25, 2003·Diabetes Care·Jerry L Nadler
Nov 5, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Cristiane Hermes SalesCélia Colli
Sep 5, 2006·Archives of Biochemistry and Biophysics·Andrea Romani
Mar 20, 2018·Nutrition & Diabetes·Tina H T ChiuChin-Lon Lin
Dec 6, 2017·European Journal of Nutrition·Maryam SafabakhshGity Sotoudeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.