PMID: 3759Feb 24, 1976Paper

Impaired urinary acidification in the hypothyroid rat

Pflügers Archiv : European journal of physiology
U F MichaelC A Vaamonde

Abstract

Since abnormalities in the renal handling of sodium and water in both the proximal and distal tubule have been described in primary hypothyroidism, this study was undertaken to examine renal tubular hydrogen secretion in this disorder. Metabolic acidosis was induced in hypothyroid rats (H) and their age matched controls (C) by the administration of an oral ammonium chloride load of 0.15 g/24 h/kg for three days. On day 3 animals were prepared for clearance and acid-base studies, receiving an infusion of Ringer's solution of 0.6 ml/hr/100 g during surgery and the experimental procedure. A 26% decrease in GFR (P less than 0.005) and a doubling in fractional excretion of sodium (P less than 0.02) were observed in H rats. The lowest blood pH and average bicarbonate concentration and the excretion of chloride were similar in the two groups, indicating that the acid load was reabsorbed and led to similar degrees of systemic acidification. Urine flow also was comparable in the two groups. Minimal urine pH after NH4Cl was 6.21 +/- 0.06 in H and 5.68 +/- 0.09 in C (P less than 0.001). Ammonium excretion was 28% (P less than 0.05) lower in H than in C. The defect in urine acidification in H was only partially corrected after 5 days on a ...Continue Reading

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Citations

Mar 12, 2009·Pflügers Archiv : European journal of physiology·Carsten A WagnerNilufar Mohebbi
Oct 1, 1987·Kidney International·G CapassoR Kinne
Jan 10, 2009·General and Comparative Endocrinology·Ingrid van Hoek, Sylvie Daminet
Oct 30, 2015·Journal of Endocrinological Investigation·Mariadelina SimeoniGiorgio Fuiano
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Nilufar MohebbiCarsten A Wagner
Dec 18, 2013·Internal Medicine Journal·A K H Lim, M J Choi

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