PMID: 185913Oct 1, 1976

Impaired urinary concentrating ability and cyclic AMP in K+-depleted rat kidney

The American Journal of Physiology
N Beck, S K Webster

Abstract

The possibility that an alteration of the vasopressin-dependent cyclic AMP system plays a pathogenic role in the urinary concentrating defect in K+ depletion was investigated in the rat. The antidiuretic response to vasopressin was significantly less in K+-depleted rats. In these K+-depleted rats, the increase in urinary cyclic AMP excretion in response to vasopressin was also significantly less. However, repletion of K+ for 1 wk by feeding high-K+ diets restored the ability to increase urinary cyclic AMP excretion in response to vasopressin. In the in vitro incubation of renal medullary slices, the increase in cyclic AMP concentration in response to vasopressin was also significantly less in the slices obtained from K+-depleted rats than in those obtained from control rats. These findings suggest that, in K+ depletion, there is a reversible impairment of the vasopressin-dependent cyclic AMP system in the renal medulla; this impairment may play a pathogenic role in the urinary concentrating defect in K+ depletion.

Citations

Dec 1, 1984·Journal of Clinical Pathology·D S O'Reilly
Sep 21, 2000·American Journal of Physiology. Renal Physiology·Hassane AmlalManoocher Soleimani
Sep 23, 2003·The Journal of Physiology·Hassane AmlalManoocher Soleimani
Apr 2, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yayoi Tsukada TetsuouKoichi Tamura
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Un Sil JeonH Moo Kwon
May 28, 2004·American Journal of Physiology. Cell Physiology·Xiangyang XuBruce C Kone
May 25, 2012·American Journal of Physiology. Renal Physiology·Louise C EvansMatthew A Bailey
Aug 1, 1988·Postgraduate Medical Journal·B WilliamsJ Walls
Sep 4, 2003·American Journal of Physiology. Renal Physiology·Ju-Young JungJin Kim
Mar 22, 2021·American Journal of Physiology. Renal Physiology·Lama Al-QusairiPaul A Welling

Related Concepts

Cyclic AMP, (R)-Isomer
Diet
Glomerular Filtration Rate
Kidney
Kidney Concentrating Ability
Potassium Deficiency
Sodium
Pitressin

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