Impaired utilization of exogenous amino acids after surgery for subarachnoid haemorrhage

Acta neurochirurgica
K HersioM Luukkonen

Abstract

We studied the metabolic response to acute aneurysm surgery and its modification by parenteral nutrition. Forty-eight patients receiving perioperative corticosteroid treatment were randomly assigned to receive glucose alone (7.2 kcal/day, D5W + C), glucose and a conventional amino acid solution (7.2 kcal/day and 0.15 gN/day, CAA + C) or glucose and branched chain amino acid enriched solution (7.2 kcal/day and 0.14 gN/day, BCAA + C). Twenty patients without corticosteroid treatment received either glucose alone (7.2 kcal/day, D5W) or glucose and a conventional amino acid solution (7.2 kcal/day and 0.14 gN/day, CAA). Poor nitrogen utilization was indicated by strongly negative nitrogen balance in all groups and a failure of the infused amino acids to improve nitrogen balance. (Day 0; D5W + C: -9.3 +/- 3.6 g/day and CAA + C: -8.2 +/- 9.7 g/day vs CAA: -2.6 +/- 4.9 g/day, p less than 0.05, Day 1; D5W + C: -14.9 +/- 9 g/day vs CAA: -7.7 +/- 6.5 g/day, p less than 0.05, MANOVA). We conclude that subarachnoid haemorrhage and its surgical treatment induce a catabolic response and impaired utilization of exogenous nitrogen, further amplified by perioperative corticosteroids, which is in sharp contrast to the response to surgery not invo...Continue Reading

References

Nov 1, 1979·Neurosurgery·P Steinbok, G Thompson
Mar 1, 1978·Metabolism: Clinical and Experimental·D H ElwynJ M Kinney
Jan 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·R ChioléroE Jéquier
Nov 1, 1986·Annals of Surgery·D Piccolboni
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·L OttC McClain
Nov 1, 1987·Journal of Neurosurgery·B YoungR Dempsey
Feb 1, 1986·Journal of Neurosurgery·C J McClainB Young
Nov 1, 1985·Journal of Neurosurgery·C S RobertsonJ C Goodman
Feb 1, 1984·Journal of Neurosurgery·P GadisseuxD P Becker
Feb 1, 1984·The Journal of Clinical Investigation·P S SimmonsM W Haymond
Jan 1, 1984·Nephron·J GrothM Mebel
Apr 1, 1984·Journal of Neurosurgery·G L CliftonC Garza
Sep 1, 1983·Journal of Neurosurgery·G L CliftonR G Grossman
Mar 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·K G AlbertiD G Johnston
Aug 1, 1982·Archives of Biochemistry and Biophysics·M E Tischler, J M Fagan
Aug 1, 1986·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J Takala, J Klossner

❮ Previous
Next ❯

Citations

Feb 7, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mirella BoselliFederica Boschi
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Chamila GeeganagePhilip M W Bath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
O PitkänenA Kari
Metabolism: Clinical and Experimental
L Jorfeldt, A Juhlin-Dannfelt
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
H StjernströmL Jorfeldt
© 2021 Meta ULC. All rights reserved