Impaired vascular function in asymptomatic young adult survivors of Hodgkin Lymphoma following mediastinal radiation.

Journal of Cancer Survivorship : Research and Practice
Shayna ZelcerFarid H Mahmud

Abstract

Mediastinal radiation can accelerate atherosclerosis in Hodgkin lymphoma survivors (HLS), and early detection is optimal. Peripheral arterial tonometry (PAT), a non-invasive measure of endothelial function, is a surrogate marker of sub-clinical atherosclerosis. The objective of our study was to evaluate endothelial function in HLS and controls using PAT and to determine the influence of mediastinal radiation. Cross-sectional evaluation was performed on 26 HLS aged 12-30 years who were a minimum of 2 years from therapy, and their healthy age and gender matched controls. Evaluation included assessment for cardiovascular risk factors and completion of the Habitual Activity Estimation Score (HAES) questionnaire to assess activity level. Endothelial Function was measured using PAT hyperemia ratios (PAT-HR). HLS and controls were similar for baseline variables (mean age 23.3 +/- 5 yrs vs. 23.4 +/- 4.8 yrs, p = 0.92). HLS were on average 6.7 +/- 4.6 yrs post treatment. No differences in endothelial function or cardiovascular risk factors were observed between HLS and controls. However, impaired endothelial function, as evidenced by lower PAT-HR (1.67 +/- 0.39 vs. 2.03 +/- 0.37, p < 0.01) was seen in HLS (n = 13) who received mediastin...Continue Reading

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Citations

Mar 30, 2012·Journal of Cardiovascular Translational Research·Daniel A MulrooneyDaniel Duprez
Nov 16, 2012·Leukemia & Lymphoma·Elena M van Leeuwen-SegarceanuWillem-Jan W Bos
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Jan 1, 2014·Global Cardiology Science & Practice·R Jay Widmer, Amir Lerman
Feb 27, 2020·Complementary Medicine Research·Khalid Hamid ChangalMujeeb Abdul Sheikh

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