PMID: 9535141Apr 16, 1998Paper

Impaired vasorelaxant responses to natriuretic peptides in the stroke-prone phenotype of spontaneously hypertensive rats

Journal of Hypertension
R RussoM Volpe

Abstract

We have previously shown that a locus on rat chromosome 5, termed STR 2, co-localizes with the genes encoding atrial natriuretic and brain natriuretic peptides, and is closely linked to the development of strokes in rats of a F2 hybrid cohort obtained by crossing stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats. We also demonstrated that there are significant differences in vascular functioning that are co-segregated with stroke latency of stroke-prone spontaneously hypertensive rats. To investigate the vascular responses to natriuretic peptides in the stroke-prone phenotype of spontaneously hypertensive rats. In view of the important vasoactive properties of natriuretic peptides, we tested the vascular responses to 10(-11)-10(-9) mol/l atrial natriuretic peptide and to 10(-11)-10(-7) mol/l brain natriuretic peptide in isolated rings of aortas and internal carotid arteries obtained from stroke-prone and stroke-resistant spontaneously hypertensive rats. The 6-week-old rats were exposed for 4 weeks either to their regular diet (n = 15 of both strains) or to the stroke-permissive Japanese-style diet (n = 14 of both strains). A group of 14 normotensive, age-matched and sex-matched Wistar-Kyoto rats w...Continue Reading

References

May 1, 1976·The American Journal of Physiology·A NagaokaK Okamoto
Sep 1, 1989·American Journal of Hypertension·P HametJ Tremblay
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D G GardnerJ A Lewicki
Jul 1, 1988·American Journal of Hypertension·M KuriharaJ M Saavedra
Jan 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·R GarciaJ Genest
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

❮ Previous
Next ❯

Citations

Feb 3, 2005·Current Hypertension Reports·Francesco Cosentino, Massimo Volpe
Jan 29, 2002·Journal of Cardiovascular Pharmacology·F CosentinoM Volpe
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·L SironiE Gianazza
Sep 8, 2000·Journal of Cardiovascular Pharmacology·M Volpe, F Cosentino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.