Impaired verbal episodic memory in healthy older adults is marked by increased F2 -Isoprostanes

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Luke A DowneyCon Stough

Abstract

Age-associated cognitive decline amongst otherwise healthy older individuals is a multifaceted characteristic of ageing. The role of oxidative stress biomarkers has been increasingly examined in the context of pathological aging conditions that affect cognition. Plasma F2-Isoprostane levels are a reliable index of systemic oxidative stress (specifically lipid peroxidation) and are elevated in dementia patients. Less is known about their role in healthy cognitive ageing. This study evaluated the relationship between F2-Isoprostanes and cognitive functioning in a cohort of 211 healthy elderly adults (60-75 years: Male; 88, Female; 123). Cognitive assessment included the Cognitive Drug Research (CDR) computerised assessment battery, which produces five validated factor scores (corresponding to 'Quality of Episodic Memory', 'Speed of Memory', Quality of Working Memory', Power of Attention' and 'Continuity of Attention'). Participants with higher F2-Isoprostane levels had significantly lower Quality of Episodic Memory scores (suggesting inferior abilities in retaining and retrieving verbal information in episodic memory). This is, to our knowledge, the first report of compromised verbal episodic memory in healthy ageing humans being...Continue Reading

Citations

May 6, 2019·Psychopharmacology·Mrudhula KomanduriCon Stough
May 10, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Onno N GroeneveldGeert Jan Biessels
Oct 1, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Chris J Edgar, Helen Brooker
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-KarpowiczZenon Dionizy Mariak
Jan 28, 2021·Antioxidants·Ashley K PutmanLorraine M Sordillo

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