PMID: 7940427Sep 1, 1994Paper

Impaired voluntary drive to breathe: a possible link between depression and unexplained ventilatory failure in asthmatic patients

G M AllenD K McKenzie


Although psychological distress predicts mortality in asthma, an underlying physiological link has not been shown. This study examined relations between impaired voluntary drive to breathe and measures of mood states. The level of maximal voluntary activation of the diaphragm and elbow flexors was measured in a previous study using a sensitive modification of the twitch interpolation technique in 11 asthmatic and 10 control subjects. In this study psychological distress was assessed using the Profile of Mood States questionnaire and measures of distress were compared with the muscle voluntary activation results. For the asthmatic subjects, depressed mood increased the risk of impaired maximal voluntary activation of the diaphragm by 3.5 times (95% CI 1.09 to 11.3). No such association was observed in control subjects. These results suggest that depressed mood may predispose an asthmatic patient to impaired voluntary activation of the diaphragm. Such individuals would be at increased risk of rapidly developing ventilatory failure if faced with severe airway narrowing.


Jun 1, 1991·Chest·W A Whitelaw
Feb 13, 1986·The New England Journal of Medicine·S R Benatar
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·L M Reid
Nov 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·O M RutherfordD J Newham
Sep 23, 1982·The New England Journal of Medicine·C Roussos, P T Macklem
Jul 1, 1993·Respiration Physiology·G M AllenS Bass


Jun 5, 2003·Journal of Psychosomatic Research·Mónika KovácsSándor Szedmák
May 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nancy K Ostrom
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S RietveldThomas L Creer
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D GozalR M Harper
May 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·B D Miller, B L Wood
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·American Thoracic Society/European Respiratory Society
Jun 27, 2003·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Martin J Tobin
Mar 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hanna TrzcińskaSebastian Derdowski
Jun 7, 2000·Journal of General Internal Medicine·C A MancusoM E Charlson
Dec 1, 1996·Perceptual and Motor Skills·N Blanc-GrasJ Gallego
Jul 8, 2008·The Journal of Allergy and Clinical Immunology·B Bender, Lening Zhang
Oct 17, 2007·The Psychiatric Clinics of North America·Ganesh ShanmugamE Sherwood Brown
Jul 3, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anthony C A Yii, Mariko S Koh
Aug 30, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Qian-Li XuePaulo H M Chaves
Aug 24, 2000·Respiratory Medicine·S CentanniA Piazzini
Feb 1, 1995·Journal of Speech and Hearing Research·A L WinkworthE Ellis
Jan 10, 2019·American Journal of Respiratory and Critical Care Medicine·Amal JubranMartin J Tobin
Aug 8, 2018·Assistive Technology : the Official Journal of RESNA·Yann MorèreEmmanuelle Blangy
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·S Rietveld, Thomas L Creer
Sep 7, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Julie Von BehrenAlexandra Hernandez
Oct 3, 2001·Physiological Reviews·S C Gandevia
Jun 16, 2000·Journal of the American Geriatrics Society·T RantanenJ M Guralnik

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