Impaired wound healing in a migraine patient as a possible side effect of calcitonin gene-related peptide receptor antibody treatment: A case report.

Cephalalgia : an International Journal of Headache
Sebastian WurthmannDagny Holle

Abstract

Wound healing disturbances as possible side effects of calcitonin gene-related peptide (CGRP) antibody treatment have been discussed previously but not yet described in humans. Basic research suggests that calcitonin gene-related peptide plays an important role in keratinocyte migration, vascularization and immune response and lack of calcitonin gene-related peptide may lead to impaired wound healing. A 51-year-old female migraine patient was treated with the CGRP receptor antibody erenumab for 6 months, which led to a relevant reduction of migraine days. During the treatment, two periods of severely impaired wound healing occurred after a trivial skin injury without spatial relation to the injection site. Skin biopsy confirmed a deep perivascular and interstitial lymphohistiocytic infiltrate with admixed eosinophils, ulceration of the epithelium, a heavy edema of the papillary dermis and focally thrombosed vessels. Impaired wound healing might be relevant side effects of CGRP antibody therapy and anamnesis within the course of treatment should also include possible observation of impaired wound healing or planned surgery.

References

May 8, 2002·Cephalalgia : an International Journal of Headache·L H LassenJ Olesen
Apr 24, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masaya TodaMasataka Majima
Jan 4, 2013·The Journal of Investigative Dermatology·Dennis RoggenkampGitta Neufang
Dec 24, 2014·Acta Physiologica·R D GransteinW Ding
Jan 22, 2019·Cephalalgia : an International Journal of Headache·David W Dodick
Apr 16, 2019·Headache·Smriti IyengarSheena K Aurora

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