PMID: 8965107Apr 1, 1996Paper

Impairment, disability, and handicap in multiple sclerosis. A cross-sectional study in an incident cohort in Møre and Romsdal County, Norway

Journal of Neurology
R MidgardH I Nyland

Abstract

We conducted a cross-sectional, geographically based study of functional status in an incident cohort of 124 multiple sclerosis (MS) patients with onset of disease from 1 January 1976 to 31 December 1986 in Møre and Romsdal County, Norway. The cohort comprised 58 men (46.8%) and 66 women (53.2%). One hundred and thirteen patients (91.1%) had a primary remitting course of disease and 11 (8.9%) had primary progressive MS. The mean age of onset was 33.3 years (range 14-64), and the mean duration of disease 7.8 years (range 1-23). The Minimal Record of Disability (MRD) of multiple sclerosis was applied to measure the degree of impairment, disability and handicap. The mean Kurtzke Expanded Disability Status Scale (EDSS) score was 3.76 (0-10), and the frequency distribution of the EDSS scores in the cohort was bimodal. Twenty-eight (22.6%) patients in the cohort had marked paraparesis, paraplegia of quadriplegia. Nineteen patients (15.3%) had frequent urinary incontinence, need for almost constant catheterization, or need for constant use of measures to evacuate stools. Five patients (4%) had a severe decrease in mentation or dementia. Forty-eight patients (38.7%) reported frequent problems with fatigue or fatigability preventing sus...Continue Reading

References

May 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·M GrønningS I Mellgren
Dec 26, 1987·Lancet·R E SteinM Weitzman
Jan 1, 1985·Journal of Chronic Diseases·N LaroccaP Kendall
Nov 1, 1988·Neurology·E W Willoughby, D W Paty
Jan 1, 1988·Journal of Clinical Epidemiology·T RiiseA Edland
Apr 1, 1988·Archives of Neurology·L B KruppL C Scheinberg
Jun 1, 1988·The British Journal of Medical Psychology·P B Zeldow, M Pavlou
Jan 1, 1986·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·A B KornblithH M Baum
Oct 1, 1981·The Journal of the Society of Occupational Medicine·J N Mitchell
Jan 1, 1984·Annals of the New York Academy of Sciences·R J SlaterL C Scheinberg
Oct 28, 1995·BMJ : British Medical Journal·V L Phillips
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R MidgardH Nyland
Feb 1, 1993·Brain : a Journal of Neurology·B Runmarker, O Andersen
May 1, 1996·Acta Neurologica Scandinavica·R MidgardH Nyland
Aug 11, 1951·Journal of the American Medical Association·A R MacLEAN, J BERKSON

❮ Previous
Next ❯

Citations

Oct 28, 2006·Journal of Rehabilitation Medicine·Jaana PaltamaaEsko Mälkiä
Aug 5, 2008·Journal of Neurology·Laura J JulianDavid C Mohr
Jul 10, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Regina Rendas-BaumJohn D Fisk
Jul 20, 2002·Clinical Neurology and Neurosurgery·Carolin Miltenburger, Gisela Kobelt
May 10, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Patrik Andlin-SobockiJes Olesen
Jan 1, 2009·ClinicoEconomics and Outcomes Research : CEOR·Ceri J Phillips, Ioan Humphreys
Jan 6, 2007·Scandinavian Journal of Occupational Therapy·Eva Månsson LexellJan Lexell
Jun 19, 2004·Disability and Rehabilitation·Eva Månsson, Jan Lexell
Nov 14, 2013·ISRN Neurology·Frederic BlancJérôme de Seze
Jan 6, 2010·Research in Developmental Disabilities·Sara Rosenblum, Patrice L Tamar Weiss
Jul 12, 2007·Multiple Sclerosis : Clinical and Laboratory Research·P SobockiG Kobelt
Aug 30, 2000·Multiple Sclerosis : Clinical and Laboratory Research·H CartonR Vlietinck
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·K GottbergL Widén Holmqvist
Feb 18, 1999·The Journal of Urology·S E LitwillerP E Zimmern
Jul 1, 2010·Acta Neurologica Scandinavica. Supplementum·L J StovnerJ A Zwart
Apr 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Ewa Orlewska
Mar 2, 1999·Brain : a Journal of Neurology·B SharrackG Dunn
Jun 13, 2006·Multiple Sclerosis : Clinical and Laboratory Research·U EinarssonL Widén Holmqvist
Oct 30, 2003·Multiple Sclerosis : Clinical and Laboratory Research·A LerdalT Moum
Dec 12, 2018·Archives of Physical Medicine and Rehabilitation·James S KrausePhillip Rumrill
Sep 29, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Dirk SchrieferTjalf Ziemssen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.