Impairment in explicit visuomotor sequence learning is related to loss of microstructural integrity of the corpus callosum in multiple sclerosis patients with minimal disability

NeuroImage
L BonzanoMarco Bove

Abstract

Sequence learning can be investigated by serial reaction-time (SRT) paradigms. Explicit learning occurs when subjects have to recognize a test sequence and has been shown to activate the frontoparietal network in both contralateral and ipsilateral hemispheres. Thus, the left and right superior longitudinal fasciculi (SLF), connecting the intra-hemispheric frontoparietal circuits, could have a role in explicit unimanual visuomotor learning. Also, as both hemispheres are involved, we could hypothesize that the corpus callosum (CC) has a role in this process. Pathological damage in both SLF and CC has been detected in patients with Multiple Sclerosis (PwMS), and microstructural alterations can be quantified by Diffusion Tensor Imaging (DTI). In light of these findings, we inquired whether PwMS with minimal disability showed impairments in explicit visuomotor sequence learning and whether this could be due to loss of white matter integrity in these intra- and inter-hemispheric white matter pathways. Thus, we combined DTI analysis with a modified version of SRT task based on finger opposition movements in a group of PwMS with minimal disability. We found that the performance in explicit sequence learning was significantly reduced in...Continue Reading

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Citations

Apr 19, 2013·Experimental Brain Research·Pranav J Parikh, Kelly J Cole
Apr 23, 2013·Multiple Sclerosis International·Emilia SbardellaPatrizia Pantano
Jan 14, 2016·Cerebral Cortex·Sanja BudisavljevicUmberto Castiello
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Feb 16, 2018·Frontiers in Human Neuroscience·Christian BesteTjalf Ziemssen
Aug 8, 2018·Journal of Neurology·Jost-Julian RumpfJoseph Classen
Oct 19, 2017·PloS One·Alessio SignoriLaura Bonzano
May 28, 2020·Frontiers in Physiology·Catherine FosterRichard G Wise

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