Impairment in Mismatch Negativity but not Repetition Suppression in Schizophrenia

Brain Topography
Brian A CoffmanDean F Salisbury

Abstract

Schizophrenia is characterized by impaired auditory-evoked potentials (AEPs), mismatch negativity (MMN), and sensory gating of AEPs to repeated stimuli (repetition suppression, RS). In the predictive modeling framework, MMN and RS reflect encoding of prediction error and model sharpening, respectively. We compared P50, N100, P200 RS, and pitch and duration MMN in 26 participants diagnosed with schizophrenia (SZ) and 26 matched healthy controls (HC), and assessed relationships between MMN, RS, and SZ diagnosis. RS was measured by comparing responses to individual tones presented as 5-tone groups (1 kHz, 75 dB, 50 ms, 5 ms rise/fall times, 330 ms SOA), separated by a 750 ms inter-trial interval. For MMN, the same tones were presented, with occasional pitch (1.2 kHz, 10%) or duration deviants (100 ms, 10%) interspersed. Pitch and duration MMN were reduced in SZ (p < 0.01). There were no group differences in P50 RS, N100 RS, or P200 RS (p's > 0.1). Importantly, although pitch and duration MMN both correlated with RS of AEPs within the MMN time range (p's < 0.01), SZ diagnosis predicted MMN over and above RS (p < 0.05) and shared little variance with RS in prediction of MMN amplitude (tolerance > 0.93). We suggest that reduced MMN i...Continue Reading

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Citations

Jul 1, 2020·Frontiers in Psychiatry·Kaitlin Fitzgerald, Juanita Todd
Aug 24, 2017·The European Journal of Neuroscience·Sarah M HaighDean F Salisbury
Feb 20, 2020·Schizophrenia Bulletin·Daisuke KoshiyamaKiyoto Kasai
Nov 3, 2020·Frontiers in Psychiatry·Chun Yuen FongShinsuke Koike
Apr 2, 2019·Psychiatry Research. Neuroimaging·Derek J FisherPhilip G Tibbo

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Software Mentioned

NCH
BrainVision Analyzer
Tone Generator
BrainVision Analyzer2
EEGLAB

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