Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supplemented with citrulline compared with arginine

Clinical Science
Sylwia OsowskaChristophe Moinard

Abstract

Arginine homoeostasis is impaired in short bowel syndrome, but its supplementation in short bowel syndrome patients remains controversial. Recently, we demonstrated the benefits of citrulline supplementation by the enteral route in resected rats. Since the first step in managing short bowel syndrome is to initiate total parenteral nutrition, we hypothesized that parenteral citrulline supplementation would be more appropriate in this situation than arginine supplementation. In the present study, 24 rats were assigned to four groups. The sham group underwent transection whereas the three other groups underwent resection (R) of 80% of the small intestine. All rats were then fed exclusively by total parenteral nutrition as follows: supplementation with citrulline (R+CIT), with arginine (R+ARG) or no supplementation (R). All of the rats received isocaloric and isonitrogenous nutrition for 4 days. Nitrogen balance was measured daily. Rats were then killed and the blood was collected and the intestinal mucosa and extensor digitorum longus muscle were removed for amino acid and protein analysis. Citrulline and arginine increased mucosal protein content in the ileum (compared with sham and R, P<0.05). However, only citrulline prevented ...Continue Reading

References

Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·G Grimble
Apr 1, 1972·The American Journal of Physiology·R B Drotman, R A Freedland
Feb 1, 1995·The British Journal of Nutrition·J P De BandtJ Giboudeau
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L CastilloV R Young
Nov 24, 1998·Metabolism: Clinical and Experimental·F DumasO Goulet
May 1, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T Segovia-SilvestreM Farriol
Feb 23, 2005·Nutrition·C LoïC Moinard
Mar 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Christophe MoinardJean-Pascal de Bandt
Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Scott R CollierJill A Kanaley
May 27, 2005·Pediatric Surgery International·Igor SukhotnikEitan Shiloni
Aug 6, 2005·Amino Acids·E CurisL Cynober
Feb 14, 2006·The American Journal of Clinical Nutrition·Sidney M Morris
Apr 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·S OsowskaC Moinard
Jan 9, 2007·The American Journal of Clinical Nutrition·Marcel C G van de PollCornelis H C Dejong
Mar 10, 2007·The Journal of Physiology·Marcel C G van de PollCornelis H C Dejong
May 22, 2007·The Journal of Nutrition·Christophe Moinard, Luc Cynober

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Citations

Mar 19, 2014·Annales pharmaceutiques françaises·S BahriS Sfar
Jul 19, 2013·Amino Acids·Mirelle Lomar VianaValbert Nascimento Cardoso
Mar 5, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Prasanthi JegatheesanJean-Pascal De-Bandt
Oct 2, 2012·Nutrition·Senda BahriSouad Sfar
Nov 4, 2010·Burns : Journal of the International Society for Burn Injuries·Bing XieZhao-fan Xia
Aug 20, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Luc CynoberJean-Pascal De Bandt
Jan 16, 2013·Fundamental & Clinical Pharmacology·Shilpa N KaoreNavinchandra M Kaore
Feb 14, 2015·Amino Acids·C BreuillardC Moinard
Apr 29, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pascal CrennLuc Cynober
Aug 24, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Iara Eliza Pacífico QuirinoMaria Isabel Toulson Davisson Correia
Jan 13, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Maísa Mota AntunesMaria Isabel Toulson Davisson Correia
Jun 19, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·S Oaleed NoordallyPhilippe Gottignies
Nov 17, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Pascal Crenn, Luc Cynober
Jul 4, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Jodie BrykPetar J Popovic
Nov 10, 2016·American Journal of Physiology. Endocrinology and Metabolism·Servane Le PlénierChristophe Moinard
Mar 6, 2015·The Journal of Nutrition·Daniel J HamRené Koopman

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