Impairment of autonomic nervous system activity in patients with pulmonary arterial hypertension: a case control study

Journal of Cardiac Failure
Stavros DimopoulosSerafim Nanas

Abstract

Chronotropic response to exercise (CR) and heart rate recovery (HRR) immediately after exercise are indirect indices of sympathetic and parasympathetic activity, respectively. The aim of this study was to evaluate CR and HRR in patients with pulmonary arterial hypertension (PAH) in relation to disease severity. Ten PAH patients (6 females/4 males, mean age: 48+/-12 years) and 10 control subjects matched for age, gender, and body mass index (6 females/4 males, mean age: 46+/-6 years) performed a ramp incremental symptom-limited cardiopulmonary exercise test on a cycle ergometer. Main measurements included heart rate at rest (HR), CR=[(peak HR-resting HR/220-age-resting HR)x100, %], HRR(1)=HR difference from peak exercise to 1minute after, ventilatory efficiency during exercise (VE/VCO(2) slope), peak oxygen uptake (VO(2)p), and the first-degree slope of VO(2) for the first minute of the recovery period (VO(2)/t-slope). PAH patients had a significantly decreased CR (58+/-31 vs 92+/-13, %, P < .001) and HRR(1) (10+/-5 vs 29+/-6, beats/min, P < .001) as well as VO(2)p (11.9+/-3.5 vs 26.9+/-6.6, mL.kg.min) and VO(2)/t-slope (0.2+/-0.1 vs. 0.9+/-0.2, mL.kg.min(2)) compared with controls. CR and HRR(1) correlated well with VO(2)p (r=0...Continue Reading

References

Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·R PeriniA Veicsteinas
Feb 1, 1984·The American Review of Respiratory Disease·J E HansenK Wasserman
Jul 30, 1999·American Heart Journal·S J KeteyianS Goldstein
Sep 16, 2000·JAMA : the Journal of the American Medical Association·E O NishimeM S Lauer
Jun 1, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·S N. Sanyal, K Ono
Feb 27, 2004·European Journal of Heart Failure·Laurent FauchierJean Paul Fauchier
Jun 5, 2004·The European Respiratory Journal·G DeboeckR Naeije
Jul 14, 2004·Chest·Vallerie V McLaughlinUNKNOWN American College of Chest Physicians
Sep 1, 2004·Circulation·Sonia Velez-RoaPhilippe van de Borne
Dec 24, 2005·International Journal of Cardiology·Serafim NanasJohn Nanas
Jan 3, 2006·The European Respiratory Journal·S ProvencherG Simonneau
Feb 2, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Stavros DimopoulosSerafim Nanas
Nov 3, 2006·Annales de cardiologie et d'angéiologie·L FauchierP Bonnet

❮ Previous
Next ❯

Citations

Aug 10, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Benjamin Daniel FoxAvi Shimony
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Paul M Hassoun
Nov 13, 2012·American Journal of Respiratory and Critical Care Medicine·Frances S de ManAnton Vonk-Noordegraaf
Jun 12, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wei-Hua LiuZhi-Hui Zhao
Jun 15, 2013·Pulmonary Medicine·Roberta P RamosJ Alberto Neder
Dec 24, 2013·Respiratory Physiology & Neurobiology·Athanasios TasoulisSerafim Nanas
May 7, 2011·Progress in Cardiovascular Diseases·Ross Arena
Sep 29, 2011·Pacing and Clinical Electrophysiology : PACE·Stavros DimopoulosSerafim Nanas
May 15, 2013·European Journal of Pharmacology·Katya RigattoMohan K Raizada
Sep 29, 2017·Cardiovascular Research·Cathelijne E E van der BruggenFrances S de Man
May 30, 2015·The European Respiratory Journal·Debabrata BandyopadhyayRaed A Dweik
Feb 14, 2018·The European Respiratory Journal·Jason WeatheraldPierantonio Laveneziana
Sep 16, 2017·Expert Review of Cardiovascular Therapy·Ming-Sing Si, Richard G Ohye
Nov 9, 2011·Expert Review of Cardiovascular Therapy·Sercan OkutucuAli Oto
Oct 17, 2019·Frontiers in Physiology·Mylene VaillancourtSoban Umar
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Denis ChemlaPhilippe Herve
Jul 23, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Jason WeatheraldPierantonio Laveneziana
Mar 27, 2021·The European Respiratory Journal·Eva L PetersFrances S de Man

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.