Impairment of cerebral autoregulation during venovenous extracorporeal membrane oxygenation in the newborn lamb

Critical Care Medicine
L K WalkerR J Traystman

Abstract

To study the effects of venovenous extracorporeal membrane oxygenation (ECMO) on cerebral autoregulation in the newborn lamb. Animal studies, using newborn lambs, with comparison of two randomized treatment groups. Newborn lambs of mixed breed, 1 to 7 days of age, were randomized into two study groups: control animals, with jugular vein ligation but no ECMO (n = 6), and ECMO animals placed on venovenous ECMO (n = 6). Laboratory animal facilities of the Department of Anesthesiology and Critical Care Medicine at The Johns Hopkins Medical Institutions, Baltimore, MD. Animals were anesthetized with pentobarbital, intubated, and ventilated, and monitoring catheters were inserted. Control animals had their right jugular vein ligated, and a cerebral autoregulation curve was performed after 1 hr of stabilization. ECMO animals were placed on venovenous ECMO and after 1 hr of stabilization, they had a cerebral autoregulation curve performed. Cerebral autoregulation was examined by increasing intracranial pressure, thereby decreasing cerebral perfusion pressure. Intracranial pressure was increased by infusion of artificial cerebrospinal fluid into the lateral ventricle of the brain. Four ranges of cerebral perfusion pressure were evaluate...Continue Reading

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jan 1, 1990·Circulation Research·F M Faraci, D D Heistad
Jul 1, 1989·ASAIO Transactions·H L AndersonR H Barlett
Feb 2, 1989·The American Journal of Cardiology·O B PaulsonS Strandgaard
Dec 1, 1972·The Journal of Physiology·M W BradburyN R Saunders
May 1, 1984·Stroke; a Journal of Cerebral Circulation·S Strandgaard, O B Paulson

❮ Previous
Next ❯

Citations

Dec 1, 1996·Critical Care Medicine·R T Mansfield, M M Parker
Dec 15, 2005·Critical Care Medicine·Arno F J van Heijst
Jun 2, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ma IngyinnBillie L Short
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Balagangadhar R TotapallyJack Wolfsdorf
Mar 28, 2006·The Annals of Thoracic Surgery·Ivar RisnesJan Ludvig Svennevig
Dec 30, 1998·Journal of Pediatric Surgery·H C OsiovichP C Etches
Jun 1, 2005·Seminars in Perinatology·Billie Lou Short
Oct 30, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Carlos A ZamoraAylin Tekes
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·B L Short
Nov 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Britt McILwainAkhil Maheshwari
Aug 27, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christian J HunterAndrew O Hopper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.