Impairment of cognitive function reported by patients suffering from carcinoid syndrome.

World Journal of Surgery
Anthony J ChambersJean Jones

Abstract

Carcinoid syndrome (CS) is characterized by symptoms of diarrhea, flushing, bronchospasm, and valvular heart disease. It has been our impression that patients with CS also exhibit features of cognitive impairment. The purpose of this pilot study was to evaluate if symptoms of cognitive impairment were reported by patients with CS. Patients with proven CS completed a 38-question multiple-ability self-report questionnaire (MASQ) to assess symptoms in five cognitive domains: language skills, attention/concentration (A/C), visual-perceptual function, visual memory, and verbal memory. Patients subsequently underwent neurocognitive assessment using a battery of six standardized tests. Results of the MASQ and the cognitive test were compared to published results for healthy individuals. Twenty-one patients with CS were studied. MASQ symptom scores were higher than published norms in all five cognitive domains. Patients reported greatest difficulty with verbal memory (mean +/- SD = 2.74 +/- 0.5), followed by A/C (2.41 +/- 0.65), language (2.31 +/- 0.55), visual memory (2.30 +/- 0.65), and visual-perceptual function (2.17 +/- 0.59). In contrast, neurocognitive tests for verbal memory immediate recall, visual memory, language, and execut...Continue Reading

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Citations

Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Tetsuhide ItoRobert T Jensen
Mar 13, 2013·Annals of Surgery·Janice L PasiekaElijah Dixon
Apr 24, 2020·Journal of Oncology·Dominique ClementRaj Srirajaskanthan
Jun 14, 2021·Comprehensive Psychiatry·Anna La SalviaFrancesco Oliva

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