PMID: 2122745Nov 1, 1990Paper

Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension

The American Journal of Physiology
W G Mayhan

Abstract

The goal of this study was to determine whether responses of the basilar artery are altered during chronic hypertension. We measured the diameter of the basilar artery using intravital microscopy in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Acetylcholine (10 microM) dilated the basilar artery by 25 +/- 4% (means +/- SE) in WKY but by only 2 +/- 2% in SHR. Bradykinin (1.0 microM) dilated the basilar artery by 12 +/- 1% in WKY, but did not alter diameter in SHR (-0.1 +/- 2%). In contrast, nitroglycerin produced similar vasodilatation in WKY and SHR. Next, we examined the possibility that impaired vasodilatation in SHR may be related to the production of a cyclooxygenase constrictor substance. Indomethacin (10 mg/kg iv) did not restore vasodilatation in response to acetylcholine and bradykinin in SHR. Finally, we examined the role of nitric oxide in dilatation of the basilar artery in response to acetylcholine and bradykinin in WKY. NG-Monomethyl-L-arginine (L-NMMA; 1.0 microM) had little effect on baseline diameter but inhibited vasodilation in response to acetylcholine and bradykinin. Vasodilatation in response to nitroglycerin was not altered by L-NMMA. These findings suggest a profound imp...Continue Reading

Citations

Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·F M Faraci, J E Brian
Jan 20, 2004·Journal of Applied Physiology·William G MayhanKaushik P Patel
Jul 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Matthew J DurandJulian H Lombard
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J E BrianS A Moore
Oct 28, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kathleen M LukaszewiczJulian H Lombard
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·W G Mayhan
Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satoru Sunano, Fumiko Sekiguchi
Apr 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Michel Félétou, Paul M Vanhoutte

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