Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety

Alimentary Pharmacology & Therapeutics
S HaagG Holtmann

Abstract

Health-related quality of life (HRQOL) is a marker of disease severity. Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet. To assess predictors for, and the impairment of, HRQOL in CLD and FD. In 181 functional dyspepsia (FD) patients, 204 CLD patients and 337 healthy blood donors, HRQOL was assessed with the Short Form-36 (mental and physical component), and anxiety and depression utilizing the Hospital Anxiety and Depression Scale. Compared with HC, HRQOL is significantly lower in FD and CLD (P-value for all <0.001). The mental but not physical component of HRQOL was significantly more impaired in FD compared with CLD (P < 0.05). After adjusting for confounders, impairment of mental (P < 0.001) and physical (P = 0.005) component of HRQOL was associated with the severity of CLD and FD. In FD, the multivariate analysis revealed depression and severity of symptoms as the most important predictors of HRQOL (R2 = 21.9 and 7.1). In CLD, the mental component of HRQOL was associated with depression and anxiety (R(2) = 9.9 and 9.7). In tertiary care, HRQOL is more se...Continue Reading

References

Mar 1, 1989·Medical Care·M Bergner
Oct 15, 1989·Annals of Internal Medicine·N J TalleyA R Zinsmeister
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GinésC Rozman
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 22, 1981·The New England Journal of Medicine·B J McNeilS G Pauker
Dec 1, 1995·Gastroenterology·N J TalleyR W Evans
Mar 1, 1995·Digestive Diseases and Sciences·N J TalleyA R Zinsmeister
Dec 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BellentaniG Cristianini
May 1, 1994·Digestive Diseases and Sciences·G HoltmannN J Talley
Mar 28, 1996·The New England Journal of Medicine·M A Testa, D C Simonson
Mar 1, 1996·Gastroenterology Clinics of North America·G R Locke
Sep 18, 1997·JAMA : the Journal of the American Medical Association·M MooreK G Castro
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G R FosterH C Thomas
Feb 25, 1998·Journal of Clinical Epidemiology·D H KuykendallN P Wray
Jul 22, 1998·The American Journal of Gastroenterology·Z M Younossi, G Guyatt
Aug 24, 1999·Gut·N J TalleyG N Tytgat
Sep 13, 2000·Gastroenterology·I M GralnekE A Mayer
May 30, 2001·Journal of Clinical Epidemiology·G UnalR A de Man
Feb 12, 2002·Digestive Diseases and Sciences·Joan MonésTina Guerrero
Oct 3, 2002·The American Journal of Gastroenterology·Natasha A KoloskiPhilip M Boyce
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·H B El-Serag, N J Talley
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Winfried HäuserDaniel Grandt
Apr 17, 2004·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jordi AlonsoUNKNOWN IQOLA Project Group
Sep 15, 2004·Archives of Internal Medicine·Brennan M R SpiegelBruce Naliboff
Nov 27, 2004·Psychosomatic Medicine·Winfried HäuserDaniel Grandt
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E AvisJaneen Manuel
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael P JonesMichael D Crowell

❮ Previous
Next ❯

Citations

Jan 30, 2013·Nature Reviews. Gastroenterology & Hepatology·Lukas Van Oudenhove, Qasim Aziz
Dec 23, 2009·World Journal of Gastroenterology : WJG·Klaus BielefeldtSusan L Zickmund
Jun 2, 2012·World Journal of Gastroenterology : WJG·Xiao-Jing LiLan Zhang
Dec 17, 2009·Journal of Psychosomatic Research·José M De la Roca-ChiapasAlma Rosa-Zarate
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·L Van OudenhoveJ Tack
Mar 30, 2011·Alimentary Pharmacology & Therapeutics·P AroJ Ronkainen
Apr 2, 2015·Journal of Gastroenterology and Hepatology·Akihito NagaharaSumio Watanabe
Oct 10, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S HaagG Holtmann
Mar 17, 2010·Zeitschrift für Psychosomatische Medizin und Psychotherapie·Ute MartensIsa Sammet
Jun 7, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Yann Le StratCaroline Dubertret
Jan 15, 2015·Journal of Gastroenterology·Hiroto MiwaUNKNOWN Japanese Society of Gastroenterology
Jan 13, 2011·Arquivos De Gastroenterologia·Pâmela Schitz Von ReisswitzCarlos Fernando de Magalhães Francisconi
Apr 30, 2017·Gut and Liver·Nicholas J Talley
Jan 6, 2009·Current Opinion in Gastroenterology·Eamonn M M Quigley, John Keohane
Feb 13, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yu WangCun-Zhi Liu
May 4, 2018·Health and Quality of Life Outcomes·Ibnu Fajariyadi HantoroMurdani Abdullah
Mar 10, 2017·World Journal of Gastroenterology : WJG·Sally WoodhouseSimon R Knowles
Mar 30, 2016·World Journal of Gastroenterology : WJG·Li-Jun DuNing Dai
Mar 6, 2009·Current Opinion in Supportive and Palliative Care

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.