PMID: 3171087Jun 1, 1988

Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats

Journal of the Autonomic Nervous System
Anthony J M VerberneW J Louis


The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.


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Related Concepts

Diastolic Blood Pressure
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Rats, Inbred SHR
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Rats, Inbred WKY
Reflex Action

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