PMID: 3171087Jun 1, 1988

Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats

Journal of the Autonomic Nervous System
Anthony J M VerberneW J Louis

Abstract

The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.

References

Oct 22, 1979·The American Journal of Cardiology·P ThorénS E Ricksten
Sep 1, 1979·Acta Physiologica Scandinavica·P ThorénS E Ricksten
Dec 1, 1974·The Journal of Clinical Investigation·D L EckbergF M Abboud
Nov 1, 1970·Acta Physiologica Scandinavica·B Oberg, S White
Jul 1, 1982·Cardiovascular Research·J T Shepherd
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Citations

Mar 14, 2008·Journal of Molecular Neuroscience : MN·Emma J SparyTrevor F C Batten
Aug 1, 1996·Progress in Neurobiology·Y MisuH Okamura
Feb 19, 2004·Brain Research. Molecular Brain Research·Sikha SahaTrevor F C Batten
Mar 29, 2003·Brain Research. Brain Research Reviews·Anthony J M VerberneDaniela M Sartor
Apr 14, 1997·Journal of the Autonomic Nervous System·S S MeyrellesE C Vasquez
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·W T Talman, S J Lewis
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·H OhtaM J Brody
Jul 24, 2007·Experimental Physiology·Eric K A CorbettTrevor F C Batten
Oct 7, 2014·Autonomic Neuroscience : Basic & Clinical·Vera GeraldesIsabel Rocha
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E C VasquezA M Cabral
Jun 5, 1998·The American Journal of Physiology·E MartelJ L Cuche

Related Concepts

Metazoa
Diastolic Blood Pressure
Diastole
Heart
Pulse Rate
Lung
Rats, Inbred SHR
August Rats
Rats, Inbred WKY
Reflex Action

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