Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress

Arteriosclerosis, Thrombosis, and Vascular Biology
Witold KorytowskiAlbert W Girotti

Abstract

Oxidative stress associated with cardiovascular disease can produce various oxidized lipids, including cholesterol oxides, such as 7-hydroperoxide (7-OOH), 7-hydroxide (7-OH), and 7-ketone (7=O). Unlike 7=O and 7-OH, 7-OOH is redox active, giving rise to the others via potentially toxic-free radical reactions. We tested the novel hypothesis that under oxidative stress conditions, steroidogenic acute regulatory (StAR) family proteins not only deliver cholesterol to/into mitochondria of vascular macrophages, but also 7-OOH, which induces peroxidative damage that impairs early stage reverse cholesterol transport. Stimulation of human monocyte-derived THP-1 macrophages with dibutyryl-cAMP resulted in substantial upregulation of StarD1 and ATP-binding cassette (ABC) transporter, ABCA1. Small interfering RNA-induced StarD1 knockdown before stimulation had no effect on StarD4, but reduced ABCA1 upregulation, linking the latter to StarD1 functionality. Mitochondria in stimulated StarD1-knockdown cells internalized 7-OOH slower than nonstimulated controls and underwent less 7-OOH-induced lipid peroxidation and membrane depolarization, as probed with C11-BODIPY (4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-inda-cene-3-un...Continue Reading

References

Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Jan 1, 1989·Free Radical Biology & Medicine·L L Smith, B H Johnson
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·G M ChisolmP E DiCorleto
Nov 1, 1995·Atherosclerosis·K ClareM J Mitchinson
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J McNeishO L Francone
May 10, 2000·Nature Structural Biology·Y Tsujishita, J H Hurley
Apr 27, 2002·Annals of the New York Academy of Sciences·Geoffrey F KelsoMichael P Murphy
Jan 18, 2003·The Journal of Biological Chemistry·Genevieve EscherDmitri Sviridov
May 2, 2003·The Journal of Biological Chemistry·Raymond E Soccio, Jan L Breslow
Jun 26, 2003·Annals of Medicine·Saara Vainio, Elina Ikonen
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·R Stocker, J F Keaney
Nov 1, 2005·QJM : Monthly Journal of the Association of Physicians·R OhashiC Chen
Jun 27, 2006·Biochimica Et Biophysica Acta·Clara CavelierArnold von Eckardstein
Jul 28, 2007·The Journal of Clinical Investigation·Xun WangDaniel J Rader
Jan 23, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y MaL Yin
Jun 23, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Barry J SnowUNKNOWN Protect Study Group
Sep 15, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Norihito Shibata, Christopher K Glass
Jan 10, 2013·Clinical Science·Anne Marie AllenAnnette Graham
Sep 3, 2013·Nature Reviews. Immunology·Kathryn J MooreEdward A Fisher
Sep 12, 2013·Redox Biology·Giuseppe PoliGabriella Leonarduzzi

❮ Previous
Next ❯

Citations

Jul 3, 2018·Photochemistry and Photobiology·Albert W Girotti, Witold Korytowski
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Menno Hoekstra, Theo J C Van Berkel
Jul 28, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziad Mallat
Apr 28, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Witold N NowakQingbo Xu
Aug 31, 2017·Redox Report : Communications in Free Radical Research·V HirschlerUNKNOWN San Antonio de los Cobres Study Group
May 17, 2019·Cardiovascular Research·Laurent Yvan-CharvetGiuseppe Danilo Norata
Jul 10, 2020·Antioxidants & Redox Signaling·Erica GianazzaCristina Banfi
Sep 25, 2020·Biomarkers in Medicine·Maria Ibac SawadaMarisa Passarelli
Apr 24, 2017·Cell Biochemistry and Biophysics·Albert W Girotti, Witold Korytowski
Jun 20, 2019·Biochemistry. Biokhimii︠a︡·K V Tugaeva, N N Sluchanko
Jan 17, 2020·International Journal of Molecular Sciences·So-Hyeon Hong, Kyung Mook Choi
Sep 8, 2017·Frontiers in Physiology·Xinyu YangHongcai Shang
Jan 27, 2021·Free Radical Research·Sayuri MiyamotoLucas G Viviani
Jan 29, 2021·Journal of Cellular Physiology·Jun LiHuimin Bian
Dec 28, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Dan ChenQing-Feng Pang
May 18, 2021·Atherosclerosis·Zhen-Wang ZhaoChao-Ke Tang
Nov 23, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph C Galley, Adam C Straub
Oct 12, 2021·Photochemistry and Photobiology·Albert W Girotti, Witold Korytowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.