Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation

Transplantation
S BenzUlrich T Hopt

Abstract

Graft pancreatitis is thought to be induced by ischemia/reperfusion. Animal experiments have suggested that an impaired microcirculation is crucial in this process. We have therefore studied the relevance of microcirculation in clinical pancreas transplantation. In 17 patients undergoing pancreas transplantation, tissue pO2 was monitored continuously by an electrode implanted into the pancreatic tail. A catheter was inserted in the distal part of the splenic vein of the pancreas graft. After reperfusion blood samples were taken from this catheter and blood flow was measured by the venous outflow method. The degree of graft pancreatitis was assessed by peak-C-reactive protein (CRP) defined as highest CRP within 3 days after transplantation. Tissue pO2 increased within 5 min after reperfusion. Thereafter, in most patients a transient decrease was noted, indicating impairment of nutritive perfusion. During this period there was an increasing negative correlation between peak-CRP and tissue pO2 which was highly significant at 60 min after reperfusion (r=-0.70, P<0.002). Also donor age correlated significantly with peak-CRP (r=0.64, P<0.005) and to a somewhat lesser extend with tissue pO2 60 min after reperfusion (r= -0.55, P<0.03)....Continue Reading

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Citations

Dec 26, 2001·Transplantation Proceedings·R D AllenJ R Chapman
Sep 26, 2003·Pancreas·Robert ObermaierStefan Benz
Jan 7, 2004·Pancreas·S BenzU T Hopt
Sep 26, 2008·Pancreas·Robert ObermaierPrzemyslaw Pisarski
Jun 26, 2012·Transplantation·Mathieu PageBernard Allaouchiche
Apr 13, 2013·Transplantation·Adam D BarlowMichael L Nicholson
Mar 22, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens-Christian KrögerMatthias Löhr
Jun 24, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Brigitte Vollmar, Michael D Menger
Jul 21, 2004·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·R ObermaierS Benz
Mar 14, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fauzia Q VandermeerJade J Wong-You-Cheong
Dec 21, 2012·Current Opinion in Organ Transplantation·Silvio NadalinAlfred Königsrainer
Dec 3, 2009·World Journal of Surgery·Guido WoesteChristoph Wullstein
Dec 21, 2010·Transplantation Proceedings·G WoesteW O Bechstein
Jul 1, 2008·Microvascular Research·Dirk UhlmannHelmut Witzigmann
Apr 20, 2005·The British Journal of Surgery·T HackertJ Werner
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Oliver DrognitzStefan Benz
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Klaus-D SchaserUtz Settmacher
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert ObermaierStefan Benz
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Miguel TanAbhinav Humar
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MaglioneG Brandacher
Apr 1, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Gerhard PreisslerKonrad Messmer
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M MaglioneG Brandacher
Dec 7, 2011·Journal of Medical Imaging and Radiation Oncology·Zhi-Yie Judith Tan, Kenneth Kwok-Pan Lau
Jun 25, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R OberhuberK Kotsch
Apr 28, 2004·Transplantation Proceedings·U BoggiF Mosca

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