Impairment of mitochondrial-nuclear cross talk in neutrophils of patients with type 2 diabetes mellitus

Indian Journal of Clinical Biochemistry : IJCB
Saba KhanPradyumna K Mishra

Abstract

Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that...Continue Reading

References

Oct 30, 1998·Diabetologia·J C Pickup, M A Crook
Feb 17, 2001·Molecular Biology of the Cell·C B EpsteinR A Butow
Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·P R WebbJ M Lord
May 20, 2003·Immunological Reviews·Hans-Uwe Simon
Oct 25, 2003·Cell Death and Differentiation·N A MaianskiT W Kuijpers
Dec 4, 2003·Acta Haematologica·N A MaianskiD Roos
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Sep 9, 2006·Diabetes Research and Clinical Practice·W Lee HandYvonne Vasquez
Aug 1, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T C Alba-LoureiroP Sannomiya
Nov 7, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Chiaki SudoHirokazu Murakami
Jan 15, 2008·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Jerard Kneifati-HayekRita Bellevue
Dec 30, 2008·Journal of Biochemical and Molecular Toxicology·Pradyumna K MishraKewal K Maudar
Feb 5, 2009·Journal of Internal Medicine·A Spinazzola, M Zeviani
Feb 7, 2009·Environmental and Molecular Mutagenesis·Pradyumna K MishraKewal K Maudar
Aug 26, 2009·The International Journal of Biochemistry & Cell Biology·Antonio ZorzanoManuel Palacín
Nov 10, 2009·Diabetes Research and Clinical Practice·J ShawP Zimmet
Jul 14, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Michael E WidlanskyJoseph A Vita
Aug 6, 2010·Reproductive Toxicology·Gorantla V RaghuramPradyumna K Mishra
Jan 26, 2011·Free Radical Biology & Medicine·Antonio Hernandez-MijaresVictor M Victor
Feb 10, 2011·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Gorantla V RaghuramPradyumna K Mishra
Jul 26, 2011·Nature Reviews. Immunology·Alberto MantovaniSébastien Jaillon
Nov 9, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Saba KhanPradyumna K Mishra
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenP Zimmet
Apr 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·Saba KhanPradyumna K Mishra
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes

Citations

Feb 25, 2014·International Journal of Toxicology·Pradyumna K MishraNeelam Pathak
Dec 16, 2020·Environmental Pollution·Jahnavi SharmaPradyumna K Mishra

Related Concepts

Complication
Diabetes
Diabetes Mellitus, Non-Insulin-Dependent
Disease Susceptibility
DNA Damage
Equilibrium
Ethnic Group
Glycosylated hemoglobin A
Mitochondria
Neutrophil

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Translational Research : the Journal of Laboratory and Clinical Medicine
Saba KhanPradyumna K Mishra
World Journal of Gastroenterology : WJG
Oya Uygur-BayramicliAlpaslan Mayadagli
© 2021 Meta ULC. All rights reserved