PMID: 7540094Mar 1, 1995Paper

Impairment of nitrergic-mediated relaxation of rat isolated duodenum by experimental diabetes

British Journal of Pharmacology
M A Martinez-CuestaSalvador Moncada

Abstract

1. Diabetes mellitus is associated with changes in gastrointestinal motility. The effects of experimental diabetes, induced by streptozotocin administration to rats 3-4 weeks previously, on the nitric oxide (NO)-mediated (nitrergic) relaxation of the duodenum have now been investigated. 2. The non-adrenergic, non-cholinergic (NANC) relaxation of the isolated duodenum induced by nicotine (0.3-10 microM) or the nicotinic agonist, 1,1-dimethyl-4-phenylpiperazinium (DMPP; 10 microM) was inhibited by the NO synthase inhibitor, NG-nitro-L-arginine (3-100 microM). 3. This nitrergic relaxation induced by nicotine or DMPP of the duodenum from diabetic rats was substantially smaller than that of the tissue from control rats. 4. By contrast, the relaxation of the duodenum from diabetic rats to the NO donor, nitroprusside (0.3-10 microM) was similar to that of control tissue, whereas the relaxation to ATP (0.1-3 microM) was enhanced to a small but significant degree. 5. Incubation of duodenal tissue from control rats at 4 degrees C for 72 h, which leads to neuronal disruption, significantly attenuated the relaxation to nicotine or DMPP whereas the relaxation induced by nitroprusside or ATP was not affected. Comparable cold-storage did not ...Continue Reading

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Citations

Apr 3, 2013·Purinergic Signalling·Geoffrey Burnstock, Ivana Novak
Aug 10, 1999·European Journal of Pharmacology·K J Way, J J Reid
Jan 29, 2000·European Journal of Pharmacology·S S OzdemA Taşatargil
Jul 18, 2001·Journal of Diabetes and Its Complications·N E Cameron, M A Cotter
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·S YonedaM Takaki
Jul 1, 1996·British Journal of Pharmacology·M A Martinez-CuestaB J Whittle
May 15, 2013·Journal of Neurogastroenterology and Motility·Ingrid DemedtsJan Tack
Sep 9, 2006·Diabetes Research and Clinical Practice·Kotaro YamadaNobuya Inagaki
Sep 2, 2011·Autonomic Neuroscience : Basic & Clinical·Joseph CelliniKathy J LePard
Feb 24, 2015·Frontiers in Medicine·Arun ChaudhuryJacqueline Nelisis Zanoni
Nov 1, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P V S JeyabalP J Pasricha
Jul 24, 2002·The American Journal of Gastroenterology·Sjoerd D KuikenGuy E E Boeckxstaens
Mar 4, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ZandeckiJ Tack
Jun 27, 2001·International Journal of Impotence Research·A GiraldiK E Andersson
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H TakaharaM Fujimiya

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