Impairment of skin barrier function is not inherent in atopic dermatitis patients: a prospective study conducted in newborns

Pediatric Dermatology
Katsuko KikuchiHachiro Tagami

Abstract

We conducted a cohort study to determine whether the barrier dysfunction of the stratum corneum that facilitates the penetration of various exacerbating agents from the environment is inherent in atopic dermatitis patients as suggested by some dermatologists. Clinical observation and biophysical measurements of the skin were performed on the cheek and on the flexor forearm of 24 newborn infants once between 2 and 14 days postnatally and 1, 3, and 6 months later. Nineteen had atopic family histories. Most of the infants had physiologic neonatal xerosis that was observed as a reduced high-frequency conductance without any impairment in the stratum corneum barrier function assessed by transepidermal water loss. Four of the 24 neonates developed atopic dermatitis around 2 to 3 months after birth. In all of them, barrier impairment noted as increased transepidermal water loss was observed only after the development of skin lesions. During their neonatal period, their transepidermal water loss and skin surface hydration state were indistinguishable from those of the neonates whose skin remained lesion-free during the observation period. Therefore, we concluded that the barrier impairment found in atopic dermatitis is not inherent but...Continue Reading

References

May 1, 1977·Medical & Biological Engineering & Computing·G E Nilsson
Jan 1, 1977·Scandinavian Journal of Gastroenterology·O KoldkjaerK G Schmidt
Sep 1, 1992·The British Journal of Dermatology·M FartaschT L Diepgen
Aug 1, 1991·The British Journal of Dermatology·T Agner
Jun 1, 1991·Pediatric Dermatology·S Saijo, H Tagami
Dec 1, 1980·The Journal of Investigative Dermatology·H TagamiB Ichijo
Aug 26, 2000·Journal of Dermatological Science·M MatsumotoM Uehara
Feb 13, 2001·The British Journal of Dermatology·A AioiH Matsuda
Sep 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BöhmeC F Wahlgren

❮ Previous
Next ❯

Citations

Oct 12, 2012·Cell and Tissue Research·Anthony V Rawlings, Rainer Voegeli
Aug 10, 2010·Journal of the American Academy of Dermatology·Eric L SimpsonJon M Hanifin
May 7, 2009·The British Journal of Dermatology·R VoegeliJ W Fluhr
Oct 5, 2011·The British Journal of Dermatology·J W FluhrJ-P Hachem
Jun 27, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ota NaokoHonda Mitsuyoshi
Apr 1, 2010·Experimental Dermatology·Joachim W FluhrEnzo Berardesca
Apr 19, 2015·Clinics in Dermatology·Marty O VisscherMauricio Odio
Feb 12, 2015·PloS One·Mark D A van LogtestijnReiko J Tanaka
Jun 5, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·L YeM-Q Man
Jan 7, 2014·Environmental Geochemistry and Health·Jian ChenDun Wu
Feb 12, 2017·Current Allergy and Asthma Reports·Anna R SmithJulia A Wisniewski
Jun 8, 2011·Pediatrics·Amy S PallerGeorgios N Stamatas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.