Impairment of striatal mitochondrial function by acute paraquat poisoning

Journal of Bioenergetics and Biomembranes
A CzerniczyniecS Lores-Arnaiz

Abstract

Mitochondria are essential for survival. Their primary function is to support aerobic respiration and to provide energy for intracellular metabolic pathways. Paraquat is a redox cycling agent capable of generating reactive oxygen species. The aim of the present study was to evaluate changes in cortical and striatal mitochondrial function in an experimental model of acute paraquat toxicity and to compare if the brain areas and the molecular mechanisms involved were similar to those observed after chronic exposure. Sprague-Dawley rats received paraquat (25 mg/Kg i.p.) or saline and were sacrificed after 24 h. Paraquat treatment decreased complex I and IV activity by 37 and 21 % respectively in striatal mitochondria. Paraquat inhibited striatal state 4 and state 3 KCN-sensitive respiration by 80 % and 62 % respectively, indicating a direct effect on respiratory chain. An increase of 2.2 fold in state 4 and 2.3 fold in state 3 in KCN-insensitive respiration was observed in striatal mitochondria from paraquat animals, suggesting that paraquat redox cycling also consumed oxygen. Paraquat treatment increased hydrogen peroxide production (150 %), TBARS production (42 %) and cardiolipin oxidation/depletion (12 %) in striatal mitochondri...Continue Reading

References

May 1, 1979·Archives of Biochemistry and Biophysics·A Gómez-PuyouE Carafoli
Jan 1, 1985·Annual Review of Biochemistry·Y Hatefi
Apr 26, 1995·Biochimica Et Biophysica Acta·C M PalmeiraV M Madeira
Jan 11, 2002·International Journal of Occupational and Environmental Health·C WesselingT J Partanen
Mar 27, 2002·Methods in Enzymology·Paul R Gardner
Jan 18, 2003·Biochimica Et Biophysica Acta·Jeanie B McMillin, William Dowhan
Aug 13, 2003·Journal of Neurochemistry·Anatoly A Starkov, Gary Fiskum
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marcia M WrightVanina Zaremberg
Sep 30, 2004·Free Radical Biology & Medicine·Juanita BustamanteAlberto Boveris
Mar 3, 2006·Neurochemistry International·Tanusree SenSasanka Chakrabarti
Jul 21, 2006·Toxicology·Guy MainwaringJonathan G Moggs
Jun 15, 2007·Free Radical Biology & Medicine·R J Dinis-OliveiraF Carvalho
Oct 17, 2007·Environmental Health Perspectives·Kavita PrasadEric K Richfield
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho
Apr 23, 2008·Current Protocols in Neuroscience·D V Madison, E B Edson
Jun 7, 2008·Experimental Biology and Medicine·Ercan GöcgeldiMetin Hasde
Feb 21, 2009·QJM : Monthly Journal of the Association of Physicians·L SenarathnaN A Buckley
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Karen BlockHanna E Abboud
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Junya KurodaJunichi Sadoshima
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia M PickrellCarlos T Moraes
Aug 2, 2011·Respiratory Physiology & Neurobiology·Raquel S SantosPatricia R M Rocco
Aug 2, 2011·Free Radical Biology & Medicine·A CzerniczyniecS Lores-Arnaiz
Apr 30, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Adam J CaseMatthew C Zimmerman
May 23, 2013·Free Radical Research·A CzerniczyniecJ Bustamante
May 8, 2015·Molecular Neurobiology·Chuen-Lin HuangNai-Kuei Huang

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Citations

Jun 22, 2016·Placenta·Ryszard MilczarekJerzy Klimek
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomás Herraiz
Jan 17, 2017·Human & Experimental Toxicology·R M SatputeP D Ambhore
May 12, 2016·Npj Aging and Mechanisms of Disease·Alejandro Martin-MontalvoRafael de Cabo
Nov 8, 2020·Journal of Chemical Neuroanatomy·Daniil S BerezhnoyTatiana N Fedorova
May 9, 2021·Archives of Biochemistry and Biophysics·Juan Santiago Adán AreánSilvia Alvarez
Jun 18, 2021·Neurochemistry International·Silvia Lores-ArnaizGeorgina Rodríguez de Lores Arnaiz

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