Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice

Nature
R C RickertJ Roes

Abstract

CD19 is the hallmark differentiation antigen of the B lineage. Its early expression has implicated a role for CD19 during the antigen-independent phases of B-cell development, whereas in mature B cells CD19 can act synergistically with surface immunoglobulin to induce activation. We have generated CD19-deficient mice and found that development of conventional B cells is unperturbed. However, mature CD19-/- B cells show a profound deficiency in responding to protein antigens that require T-cell help. This is accompanied by a lack of germinal centre formation and affinity maturation of serum antibodies. Thus CD19 is crucial for both initial B-cell activation by T-cell-dependent antigens and the maturation and/or selection of the activated cells into the memory compartment. An impairment in ligand-driven selection may also be responsible for the observation of a striking reduction in the B-1 (formerly Ly-1) B-cell subset, thought to develop under the control of self-antigens and bacterial antigens (reviewed in ref. 2).

References

Aug 1, 1990·The Journal of Experimental Medicine·B HeymanT Kinoshita
Apr 11, 1991·International Immunology·Y Liu, C A Janeway
May 1, 1991·Journal of Cellular Physiology·Y KanekoJ Fujita
Jan 1, 1994·Advances in Immunology·R R Hardy, K Hayakawa
Sep 1, 1994·Immunology Today·T F TedderP Engel
Jan 1, 1993·Immunology Today·C J van NoeselR A van Lier
Jul 1, 1993·The Journal of Experimental Medicine·M G McHeyzer-WilliamsG J Nossal

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Citations

Mar 4, 1999·European Journal of Immunology·A Gulbranson-JudgeM Turner
Oct 30, 1999·European Journal of Immunology·A MakowskaS Cardell
Jul 13, 2001·European Journal of Immunology·A R de FougerollesD T Fearon
Dec 30, 2004·Cytometry. Part B, Clinical Cytometry·Wei YangHoward Meyerson
Dec 7, 2002·Hematological Oncology·Huifeng Niu
Aug 26, 1998·Clinical Immunology and Immunopathology·M Tolnay, G C Tsokos
Jun 25, 1998·Immunologic Research·M F Bachmann
Aug 15, 2006·Modern Rheumatology·Jun SuzukiYoshinari Takasaki
Feb 6, 2002·Springer Seminars in Immunopathology·B Heyman
Feb 1, 1996·Research in Immunology·P W Dempsey, D T Fearon
Oct 1, 1995·Current Opinion in Genetics & Development·M Busslinger, P Urbánek
Jul 14, 2001·Molecular Immunology·M Boes
Sep 6, 2002·Molecular Immunology·Goutam SenSubbarao Bondada
Jul 23, 2003·Trends in Pharmacological Sciences·Matthias P WymannMuriel Laffargue
Mar 14, 1998·Research in Immunology·A Tarakhovsky
Mar 3, 2001·Current Opinion in Immunology·F Martin, J F Kearney
Apr 26, 2002·Current Opinion in Immunology·Tomohiro Kurosaki
Apr 1, 1996·Current Opinion in Immunology·M J Owen, A R Venkitaraman
Jun 1, 1996·Current Opinion in Immunology·M G McHeyzer-Williams
Jun 1, 1996·Current Opinion in Immunology·P Lane
Jun 1, 1996·Current Opinion in Immunology·G M DoodyD T Fearon
Jun 1, 1997·Current Opinion in Immunology·A Tarakhovsky
Jun 1, 1997·Current Opinion in Immunology·L O'RourkeD T Fearon
Apr 1, 1997·Current Opinion in Immunology·P D Burrows, M D Cooper
Feb 1, 1997·Current Opinion in Immunology·M C Carroll, M B Fischer
Apr 2, 1998·Current Opinion in Immunology·M C Carroll, A P Prodeus
May 29, 1998·Current Opinion in Immunology·T W LeBien
Mar 14, 2000·Current Opinion in Immunology·I Su, A Tarakhovsky
May 14, 1999·Current Opinion in Immunology·R J Benschop, J C Cambier
Apr 30, 1998·Current Opinion in Cell Biology·V L Tybulewicz
Feb 1, 1997·Current Biology : CB·L NitschkeM C Lamers
Apr 12, 2003·Seminars in Immunology·Kenji TanigakiTasuku Honjo
Jan 29, 2002·International Immunopharmacology·Nancy I Kerkvliet
Jul 21, 2010·Nature Immunology·Christopher C GoodnowRobert Brink
Mar 23, 2011·Nature Immunology·Owen M SiggsBruce Beutler

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