Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation

Journal of Cardiovascular Electrophysiology
Ta-Chuan TuanShih-Ann Chen

Abstract

Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. This study included 88 patients (age 50 +/- 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 +/- 0.49 vs 2.17 +/- 0.56 mV, P < 0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 +/- 0.67 vs 1.82 +/- 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P < 0.00...Continue Reading

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Citations

Mar 7, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Erdal AkturkHasan Pekdemir
Nov 19, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Li-Wei Lo, Shih-Ann Chen
Sep 8, 2011·International Journal of Medical Sciences·Yoko ShibataIsao Kubota
Sep 6, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Thomas F DeeringAndrew C Wikliffe
Feb 10, 2018·Journal of Cardiovascular Electrophysiology·Wen-Han ChengShih-Ann Chen

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