PMID: 7019245Jul 1, 1981Paper

Impairment of the growth of Plasmodium falciparum in HbEE erythrocytes

The Journal of Clinical Investigation
R L NagelD Labie

Abstract

HbE is a beta-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.

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Citations

Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J VernesC L Diggs
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·Y YuthavongS Fucharoen
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May 23, 2013·PLoS Pathogens·Steve M TaylorRick M Fairhurst
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Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
Jul 26, 2002·British Journal of Haematology·Thomas Neil WilliamsChristopher I Newbold
Oct 30, 2009·American Journal of Clinical Pathology·Daniel David MaisDavid F Keren
Jan 26, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sri Riyati SugiartoTimothy M E Davis
May 11, 2018·The Korean Journal of Parasitology·Jiraporn Kuesap, Kesara Na-Bangchang
Aug 1, 1987·American Journal of Hematology·N A Lachant
Jan 1, 2020·Evolution, Medicine, and Public Health·Jiwoo HaAkihiro Nishi

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