Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats.

PloS One
Renata LekeLuis V Portela

Abstract

Hepatic encephalopathy (HE) arises from acute or chronic liver diseases and leads to several problems, including motor impairment. Animal models of chronic liver disease have extensively investigated the mechanisms of this disease. Impairment of locomotor activity has been described in different rat models. However, these studies are controversial and the majority has primarily analyzed activity parameters. Therefore, the aim of the present study was to evaluate locomotor and exploratory behavior in bile duct-ligated (BDL) rats to explore the spatial and temporal structure of behavior. Adult female Wistar rats underwent common bile duct ligation (BDL rats) or the manipulation of common bile duct without ligation (control rats). Six weeks after surgery, control and BDL rats underwent open-field, plus-maze and foot-fault behavioral tasks. The BDL rats developed chronic liver failure and exhibited a decrease in total distance traveled, increased total immobility time, smaller number of rearings, longer periods in the home base area and decreased percentage of time in the center zone of the arena, when compared to the control rats. Moreover, the performance of the BDL rats was not different from the control rats for the elevated pl...Continue Reading

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Citations

Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Natalia QvartskhavaDieter Häussinger
Jul 19, 2015·Asian Journal of Surgery·Evren DilektasliCandan Ozogul
Jun 7, 2015·Physiology & Behavior·M Méndez-LópezJ L Arias
Oct 30, 2012·Biochemical Pharmacology·Sherry DadsetanHelle S Waagepetersen
Feb 26, 2015·Anais Da Academia Brasileira De Ciências·Luciana Le Sueur-MalufIsabel C Céspedes
Sep 7, 2017·Metabolic Brain Disease·Natália Ferreira MendesLuciana Le Sueur-Maluf
Nov 1, 2012·Metabolic Brain Disease·Renata LekeArne Schousboe
Feb 10, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yanqun ChangWei Wei
Apr 27, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Sharon DeMorrowChristopher F Rose
Aug 14, 2021·Clinics and Research in Hepatology and Gastroenterology·Charlotte BouzbibMarika Rudler

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Methods Mentioned

BETA
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maze®
Excel
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GraphPad Prism

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