PMID: 7542041Mar 1, 1995Paper

Impairment of the priming effect of glucose on insulin secretion from isolated islets of aging rats

Acta Diabetologica
M BombaraE Bergamini

Abstract

The time-dependent potentiation (TDP) of insulin release or priming effect exerted by glucose was evaluated in the islets of Langerhans of mature and old rats. Islets isolated from 12- and 26-month-old male Sprague-Dawley rats and incubated for two consecutive 60-min periods in the presence of various stimulating agents were unable to enhance their insulin responsiveness significantly during the second incubation period and showed other abnormalities in their sensitivity to secretagogues compared with islets from 3-month-old animals. The priming action of glucose plus arginine or isobutylmethylxanthine (IBMX) was not observed in islets from 12-month-old rats, but surprisingly, islets from senescent rats showed a restoration of the beta-cell memory in the presence of IBMX. Interestingly, the islets isolated from 2-month-old animals previously exposed to an intravenous glucose load in vivo released approximately twice as much insulin as the islets taken from fed rats not subjected to the load. This potentiation exerted by the intravenous glucose administration was reduced but not abolished in the islets of glucose-intolerant, 12-month-old rats. In conclusion, the glucose TDP of insulin secretion is impaired in islets of mature an...Continue Reading

References

Aug 1, 1979·The Journal of Clinical Investigation·E P ReavenG M Reaven
Jul 1, 1975·Acta Endocrinologica·E Cerasi
Oct 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·S TsuchiyamaY Kato
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Jan 1, 1984·Journal of Gerontology·P T BurchF M Matschinsky
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May 1, 1980·Journal of Gerontology·E ReavenG Reaven

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