Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice

Neurobiology of Aging
Éva M SzegoJörg B Schulz

Abstract

Dementia in Parkinson's disease (PDD) and dementia with Lewy bodies (DLB) are characterized by loss of acetylcholine (ACh) from cortical areas. Clinical studies report positive effects of acetylcholine esterase (AChE) inhibitors in PDD and dementia with Lewy bodies. We here report that the number of neurons expressing a cholinergic marker in the medial septum-diagonal band of Broca complex decreases in A30P α-synuclein-expressing mice during aging, paralleled by a lower AChE fiber density in the dentate gyrus and in the hippocampal CA1 field. After inducing dopamine depletion by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP), no acute but a delayed loss of cholinergic neurons and AChE-positive fibers was observed, which was attenuated by L-3,4-dihydroxyphenylalanine (DOPA) treatment. Expression of nerve growth factor (NGF) and tyrosine receptor kinase A (TrkA) genes was upregulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride-treated wild type mice, but not in A30P α-synuclein expressing animals. In contrast, upregulation of sortilin and p75(NTR) genes was found in the A30P α-synuclein-expressing mice. These results suggest that dopamine deficiency may contribute to the impairment of the sept...Continue Reading

References

Feb 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C HedreenD L Price
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jun 10, 1998·Neurobiology of Learning and Memory·C Brandner, F Schenk
Jun 18, 1998·Annals of Neurology·M D MuenterD B Calne
Feb 11, 2000·Neurology·P TiraboschiJ Corey-Bloom
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Jun 25, 2005·Brain : a Journal of Neurology·M C Rodriguez-OrozN Van Blercom
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sebastian KowskyJörg B Schulz
Apr 25, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Grazyna NiewiadomskaGernot Riedel
Jun 19, 2009·Neurology·Nicolaas I Bohnen, Roger L Albin
Feb 5, 2010·Journal of the Neurological Sciences·Kiyoe OhtaMitsuhiro Ohta
Feb 27, 2010·Developmental Neurobiology·Kenneth K TengBarbara L Hempstead
Jul 22, 2011·Journal of the Neurological Sciences·Éva M SzegoPawel Kermer

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Citations

Jun 21, 2013·Acta Neuropathologica·Iñaki-Carril MundiñanoMaria-Rosario Luquin
Feb 16, 2013·International Journal of Biological Sciences·Fangfang BiHongxia Zhou
Mar 4, 2017·PLoS Biology·Rita Machado de OliveiraTiago Fleming Outeiro
Jun 28, 2017·Brain Research·Giancarlo Pepeu, Maria Grazia Giovannini
Sep 10, 2013·The EMBO Journal·Teresa Faria PaisTiago Fleming Outeiro
Apr 12, 2017·Brain : a Journal of Neurology·Hugo Vicente MirandaTiago F Outeiro
Jul 3, 2021·Brain Sciences·Poornima D E Weerasinghe-MudiyanselageChangjong Moon
Jul 31, 2021·Frontiers in Neuroscience·Éva M SzegőBjörn H Falkenburger

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