Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress

Pharmacology, Biochemistry, and Behavior
Li SongKinzo Matsumoto

Abstract

Increasing evidences indicate the concurrence and interrelationship of depression and cognitive impairments. The present study was undertaken to investigate the effects of two depressive animal models, learned helplessness (LH) and chronic mild stress (CMS), on the cognitive functions of mice in the Morris water maze task. Our results demonstrated that both LH and CMS significantly decreased the cognitive performance of stressed mice in the water maze task. The escaping latency to the platform was prolonged and the probe test percentage in the platform quadrant was reduced. These two models also increased the plasma corticosterone concentration and decreased the brain derived neurotrophic factor (BDNF) and cAMP-response element-biding protein (CREB) messenger ribonucleic acid (mRNA) levels in hippocampus, which might cause the spatial cognition deficits. Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels. Furthermore, antidepressant treated animals showed an ameliorated cognitive performance compared with the vehicle treated stressed animals. These data suggest that both LH and CMS impair the spa...Continue Reading

References

Mar 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J L MoreauW E Haefely
Feb 1, 1990·Archives of Neurology·G S ZubenkoU Kopp
Jul 1, 1987·Behavioral and Neural Biology·M R FoyR F Thompson
May 1, 1984·Journal of Neuroscience Methods·R Morris
Apr 1, 1995·Current Opinion in Neurobiology·B S McEwen, R M Sapolsky
Apr 1, 1993·Hippocampus·C PavlidesB S McEwen
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jul 1, 1997·Archives of General Psychiatry·R S DumanE J Nestler
Aug 1, 1997·Archives of Neurology·G KuzisS E Starkstein
Nov 14, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·J L PayneA Warren
Mar 18, 2000·Psychological Medicine·E MervaalaJ Lehtonen
Aug 26, 2000·Biological Psychiatry·D C SteffensK R Krishnan
Nov 7, 2000·Biological Psychiatry·R S DumanC D'Sa
Nov 18, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·A von GuntenM A Ron
May 1, 2001·Nature Medicine·H K ManjiD S Charney
May 2, 2001·Nature Reviews. Neuroscience·M L Wong, J Licinio
Jul 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·G GainottiS Paolucci
Feb 9, 2002·Life Sciences·Kiyofumi YamadaToshitaka Nabeshima
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Jul 2, 2002·The American Journal of Psychiatry·Thomas FrodlHans-Jürgen Möller
Aug 20, 2002·Scandinavian Journal of Psychology·Barbara RavnkildeRaben Rosenberg
Aug 20, 2002·Psychopharmacology·Catherine J HarmerGuy M Goodwin
Oct 4, 2002·Biological Psychiatry·Eric J NestlerSteve Zalcman
Nov 9, 2002·Science·R J Dolan
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glenda M MacQueenL Trevor Young
Apr 25, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Reinhard HeunUrsula Ptok
Apr 26, 2003·Acta Neurologica Scandinavica·J UekermannT Müller
May 3, 2003·The American Journal of Psychiatry·George S ZubenkoTrey Sunderland
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ettore TiraboschiMaurizio Popoli

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Citations

Sep 11, 2012·Psychopharmacology·Georgina Valeria Fernández MacedoSilvia Wikinski
Aug 5, 2009·Molecular Neurobiology·Katie J McLaughlinCheryl D Conrad
Jan 30, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Darrick T BaluIrwin Lucki
Jun 10, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anita J Bechtholt-GompfBruce M Cohen
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amrita NairVidita A Vaidya
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard G HunterBruce S McEwen
Feb 13, 2008·Epilepsy Currents·Andrey Mazarati
Dec 24, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Suthat LiangpunsakulDavid W Crabb
Aug 25, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Nurmuhammat AmatHalmurat Upur
Jun 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jian-Hua LiuWen-Bin Fu
Jul 8, 2014·BioMed Research International·Mikhail StepanichevNatalia Gulyaeva
May 16, 2007·Neural Plasticity·Allan V Kalueff
Jun 16, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yifeng LuoYan Zhu
Feb 28, 2016·Journal of Psychiatric Research·Chun-Lin SuPo-Wu Gean
Sep 4, 2015·Perceptual and Motor Skills·Kwangmin RyuSteven J Radlo
Feb 18, 2012·Neurobiology of Aging·Qinxi GuoNicholas John Justice
Jan 23, 2016·Translational Psychiatry·S AslaniJ A Palha
Feb 6, 2013·Neuroscience·N PluchinoA R Genazzani

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