PMID: 9189261Jun 1, 1997Paper

Impairment of visual object-discrimination learning after perirhinal cortex ablation

Behavioral Neuroscience
M J Buckley, David Gaffan

Abstract

Eight cynomolgus monkeys learned preoperatively 20 concurrent visual discriminations between pairs of colored shapes presented on a touch screen with 24-hr intertrial intervals. Three then received bilateral perirhinal cortex ablation, and 5 remained controls. The ablated monkeys were severely impaired in reacquiring the preoperatively acquired set, whereas postoperative learning of 20 new discriminations was not significantly affected. The task was then made more difficult. First, the number of foils from which the stimulus had to be selected was increased to 2, 4, 7, and then 14. Second, larger sets of 40, 80, and 160 problems were presented. Both manipulations revealed some significant but relatively mild impairments in the monkeys with ablations. It is suggested that perirhinal cortex ablation impairs the monkey's capacity to identify individual objects, which leads to deficits in both visual-object recognition memory and discrimination learning.

Citations

Jun 10, 1998·Progress in Neurobiology·M W Brown, J Z Xiang
May 29, 2003·Neuroscience·R D Burwell, D M Hafeman
Oct 1, 1997·Trends in Cognitive Sciences·D Gaffan
May 14, 1999·Trends in Cognitive Sciences·E A Murray, T J Bussey
Nov 22, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Gaffan, J Hornak
Jan 21, 2000·Learning & Memory·E A BuffaloS M Zola
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Gaffan
Aug 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zheng LiuEdward I Ginns
Aug 9, 2006·Behavioral Neuroscience·Matthew M Campolattaro, John H Freeman
Apr 24, 2009·Cerebral Cortex·J S HoldstockC J Price
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong Sang Jo, Inah Lee
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M P NoonanM F S Rushworth
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hsiao-Wei TuElisabeth A Murray
Nov 19, 2003·The European Journal of Neuroscience·Christian HölscherJianzhong Xiang
Sep 27, 2003·The European Journal of Neuroscience·Andy C H LeeKim S Graham

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