Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder

Psychopharmacology
T V LimKaren D Ersche

Abstract

Drug addiction has been suggested to develop through drug-induced changes in learning and memory processes. Whilst the initiation of drug use is typically goal-directed and hedonically motivated, over time, drug-taking may develop into a stimulus-driven habit, characterised by persistent use of the drug irrespective of the consequences. Converging lines of evidence suggest that stimulant drugs facilitate the transition of goal-directed into habitual drug-taking, but their contribution to goal-directed learning is less clear. Computational modelling may provide an elegant means for elucidating changes during instrumental learning that may explain enhanced habit formation. We used formal reinforcement learning algorithms to deconstruct the process of appetitive instrumental learning and to explore potential associations between goal-directed and habitual actions in patients with cocaine use disorder (CUD). We re-analysed appetitive instrumental learning data in 55 healthy control volunteers and 70 CUD patients by applying a reinforcement learning model within a hierarchical Bayesian framework. We used a regression model to determine the influence of learning parameters and variations in brain structure on subsequent habit formati...Continue Reading

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Citations

Jul 11, 2019·Psychopharmacology·Shelly B FlagelMartin P Paulus
Jun 12, 2021·Der Nervenarzt·Dusan HirjakRobert Christian Wolf
Jul 2, 2021·The International Journal of Neuropsychopharmacology·Tsen Vei LimKaren D Ersche
Aug 24, 2021·Current Opinion in Behavioral Sciences·Maëlle C M GueguenAnna B Konova

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Software Mentioned

RStan
FSL
FSL ( FMRIB Software Library
dtifit
Probtrackx2
NHLAT
BedpostX
eddy
Statistical Package for the Social Sciences
R

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